mRNA 中 5-甲基胞嘧啶的分布。
The of 5-methylcytosine in messenger RNA.
机构信息
Shine-Dalgarno Centre for RNA Innovation, Division of Genome Science and Cancer, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australian Capital Territory, Australia.
Shine-Dalgarno Centre for RNA Innovation, Division of Genome Science and Cancer, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australian Capital Territory, Australia
出版信息
RNA. 2024 Apr 16;30(5):560-569. doi: 10.1261/rna.079982.124.
The potential presence of 5-methylcytosine as a sparse internal modification of mRNA was first raised in 1975, and a first map of the modification was also part of the epitranscriptomics "big bang" in 2012. Since then, the evidence for its presence in mRNA has firmed up, and initial insights have been gained into the molecular function and broader biological relevance of 5-methylcytosine when present in mRNA. Here, we summarize the status quo of the field, outline some of its current challenges, and suggest how to address them in future work.
5- 甲基胞嘧啶作为 mRNA 内部修饰的稀疏存在最早于 1975 年提出，而修饰图谱也是 2012 年转录后组学“大爆炸”的一部分。自那时以来，mRNA 中存在 5- 甲基胞嘧啶的证据得到了巩固，并且人们对其存在于 mRNA 中的分子功能和更广泛的生物学相关性有了初步的了解。在这里，我们总结了该领域的现状，概述了当前的一些挑战，并提出了如何在未来的工作中解决这些问题的建议。
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