Anas Zahra, Hasan Syeda Fatima Saba, Moiz Muhammad Abdul, Zuberi Muhammad Abdul Wasay, Shah Hussain Haider, Ejaz Aima, Dave Tirth, Panjwani Muhammad Hasnain, Rauf Sameer Abdul, Hussain Muhammad Sheheryar, Waseem Radeyah
Dow University of Health Sciences.
Bukovinian State Medical University, Chernivtsi, Ukraine.
Ann Med Surg (Lond). 2024 Feb 8;86(4):2004-2010. doi: 10.1097/MS9.0000000000001809. eCollection 2024 Apr.
Conventional therapeutic techniques for brain tumours have limitations and side effects, necessitating the need for alternative treatment options. MRI-monitored therapeutic hydrogel systems show potential as a non-surgical approach for brain tumour treatment. Hydrogels have unique physical and chemical properties that make them promising for brain tumour treatment, including the ability to encapsulate therapeutic agents, provide sustained and controlled drug release, and overcome the blood-brain barrier for better penetration. By combining hydrogel systems with MRI techniques, it is possible to develop therapeutic approaches that provide real-time monitoring and controlled release of therapeutic agents. Surgical resection remains important, but there is a growing need for alternative approaches that can complement or replace traditional methods. The objective of this comprehensive narrative review is to evaluate the potential of MRI-monitored therapeutic hydrogel systems in non-surgical brain tumour treatment.
传统的脑肿瘤治疗技术存在局限性和副作用,因此需要其他治疗选择。磁共振成像(MRI)监测的治疗性水凝胶系统显示出作为脑肿瘤非手术治疗方法的潜力。水凝胶具有独特的物理和化学性质,使其在脑肿瘤治疗方面具有前景,包括能够封装治疗剂、实现药物的持续和控释,以及克服血脑屏障以实现更好的渗透。通过将水凝胶系统与MRI技术相结合,有可能开发出能够对治疗剂进行实时监测和控释的治疗方法。手术切除仍然很重要,但越来越需要能够补充或替代传统方法的替代方法。这篇全面的叙述性综述的目的是评估MRI监测的治疗性水凝胶系统在非手术脑肿瘤治疗中的潜力。