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利用程序化协作建立放射性药物诊所。

Leveraging Programmatic Collaboration for a Radiopharmaceutical Clinic.

作者信息

Kunos Charles A, Martin Molly E, Georgiou Michalis F, Kuker Russ A, Chauhan Aman

机构信息

Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, 1475 NW 12th Avenue, Suite 1500, Miami, FL 33136, USA.

Department of Radiology, Division of Nuclear Medicine, University of Iowa Health Care, Iowa City, IA 52242, USA.

出版信息

Cancers (Basel). 2024 Apr 2;16(7):1396. doi: 10.3390/cancers16071396.

Abstract

Radiation oncologists, radiopharmacists, nuclear medicine physicians, and medical oncologists have seen a renewed clinical interest in radiopharmaceuticals for the curative or the palliative treatment of cancer. To allow for the discovery and the clinical advancement of targeted radiopharmaceuticals, these stakeholders have reformed their trial efforts and remodeled their facilities to accommodate the obligations of a program centered upon radioactive investigational drug products. Now considered informally as drugs and not beam radiotherapy, radiopharmaceuticals can be more easily studied in the traditional clinical trial enterprise ranging from phase 0-I to phase III studies. Resources and physical facilities allocated to radiopharmaceuticals have brought forth new logistics and patient experience for safe and satisfactory drug delivery. The clinical use of theranostic agents-that is, diagnostic and therapeutic radionuclide pairs-has accelerated radiopharmaceutical development.

摘要

放射肿瘤学家、放射药剂师、核医学医师和肿瘤内科医师对用于癌症治愈性或姑息性治疗的放射性药物重新产生了临床兴趣。为了促进靶向放射性药物的发现和临床进展,这些利益相关者重新调整了试验工作,并对其设施进行了改造,以适应以放射性研究药物产品为中心的项目要求。放射性药物现在被非正式地视为药物而非束流放射治疗,因此在从0-I期到III期研究的传统临床试验中更容易进行研究。分配给放射性药物的资源和物理设施带来了新的物流和患者体验,以实现安全且令人满意的药物递送。治疗诊断剂(即诊断和治疗性放射性核素对)的临床应用加速了放射性药物的开发。

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