基因组因素塑造了子囊菌酵母中碳和氮代谢生态位宽度。
Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts.
作者信息
Opulente Dana A, LaBella Abigail Leavitt, Harrison Marie-Claire, Wolters John F, Liu Chao, Li Yonglin, Kominek Jacek, Steenwyk Jacob L, Stoneman Hayley R, VanDenAvond Jenna, Miller Caroline R, Langdon Quinn K, Silva Margarida, Gonçalves Carla, Ubbelohde Emily J, Li Yuanning, Buh Kelly V, Jarzyna Martin, Haase Max A B, Rosa Carlos A, ČCadež Neža, Libkind Diego, DeVirgilio Jeremy H, Hulfachor Amanda Beth, Kurtzman Cletus P, Sampaio José Paulo, Gonçalves Paula, Zhou Xiaofan, Shen Xing-Xing, Groenewald Marizeth, Rokas Antonis, Hittinger Chris Todd
机构信息
Laboratory of Genetics, Wisconsin Energy Institute, Center for Genomic Science Innovation, J. F. Crow Institute for the Study of Evolution, University of Wisconsin-Madison, Madison, WI 53726, USA.
DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, WI 53726, USA.
出版信息
Science. 2024 Apr 26;384(6694):eadj4503. doi: 10.1126/science.adj4503.
Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance efficiency and breadth and (ii) the joint influence of extrinsic (environmental) and intrinsic (genomic) factors. We assembled genomic, metabolic, and ecological data from nearly all known species of the ancient fungal subphylum Saccharomycotina (1154 yeast strains from 1051 species), grown in 24 different environmental conditions, to examine niche breadth evolution. We found that large differences in the breadth of carbon utilization traits between yeasts stem from intrinsic differences in genes encoding specific metabolic pathways, but we found limited evidence for trade-offs. These comprehensive data argue that intrinsic factors shape niche breadth variation in microbes.
生物在生态位宽度上表现出广泛的差异，从非常狭窄（ specialists）到非常宽泛（generalists）。已经提出了两种一般范式来解释这种差异：（i）性能效率与宽度之间的权衡，以及（ii）外在（环境）和内在（基因组）因素的共同影响。我们收集了来自古代真菌亚门酵母纲几乎所有已知物种（来自1051个物种的1154个酵母菌株）的基因组、代谢和生态数据，这些菌株在24种不同环境条件下生长，以研究生态位宽度的进化。我们发现，酵母之间碳利用性状宽度的巨大差异源于编码特定代谢途径的基因的内在差异，但我们发现权衡的证据有限。这些全面的数据表明，内在因素塑造了微生物生态位宽度的变化。
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