Araújo Daniela, Silva Ana Rita, Fernandes Rúben, Serra Patrícia, Barros Maria Margarida, Campos Ana Maria, Oliveira Ricardo, Silva Sónia, Almeida Carina, Castro Joana
INIAV-National Institute for Agrarian and Veterinarian Research, Rua dos Lagidos, 4485-655 Vila do Conde, Portugal.
CEB-Centre of Biological Engineering Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.
Pathogens. 2024 Apr 13;13(4):320. doi: 10.3390/pathogens13040320.
The importance of addressing the problem of biofilms in farm, wild, and companion animals lies in their pervasive impact on animal health and welfare. Biofilms, as resilient communities of microorganisms, pose a persistent challenge in causing infections and complicating treatment strategies. Recognizing and understanding the importance of mitigating biofilm formation is critical to ensuring the welfare of animals in a variety of settings, from farms to the wild and companion animals. Effectively addressing this issue not only improves the overall health of individual animals, but also contributes to the broader goals of sustainable agriculture, wildlife conservation, and responsible pet ownership. This review examines the current understanding of biofilm formation in animal diseases and elucidates the complex processes involved. Recognizing the limitations of traditional antibiotic treatments, mechanisms of resistance associated with biofilms are explored. The focus is on alternative therapeutic strategies to control biofilm, with illuminating case studies providing valuable context and practical insights. In conclusion, the review highlights the importance of exploring emerging approaches to mitigate biofilm formation in animals. It consolidates existing knowledge, highlights gaps in understanding, and encourages further research to address this critical facet of animal health. The comprehensive perspective provided by this review serves as a foundation for future investigations and interventions to improve the management of biofilm-associated infections in diverse animal populations.
解决农场动物、野生动物和伴侣动物生物膜问题的重要性在于其对动物健康和福利的广泛影响。生物膜作为有韧性的微生物群落,在引发感染和使治疗策略复杂化方面构成持续挑战。认识并理解减轻生物膜形成的重要性对于确保各种环境下动物的福利至关重要,这些环境包括农场、野外和伴侣动物所处环境。有效解决这一问题不仅能改善个体动物的整体健康,还有助于实现可持续农业、野生动物保护和负责任养宠等更广泛目标。本综述考察了当前对动物疾病中生物膜形成的理解,并阐明了其中涉及的复杂过程。认识到传统抗生素治疗的局限性,探讨了与生物膜相关的耐药机制。重点是控制生物膜的替代治疗策略,有启发性的案例研究提供了有价值的背景和实际见解。总之,本综述强调了探索减轻动物生物膜形成新方法的重要性。它整合了现有知识,突出了理解上的差距,并鼓励进一步研究以解决动物健康这一关键方面的问题。本综述提供的全面视角为未来改善不同动物群体中生物膜相关感染管理的调查和干预奠定了基础。