三个非洲国家在经历多次不同免疫挑战后出现的严重急性呼吸综合征冠状病毒2中和抗体
SARS-CoV-2 Neutralizing Antibodies in Three African Countries Following Multiple Distinct Immune Challenges.
作者信息
Ny Mioramalala Diary Juliannie, Ratovoson Rila, Tagnouokam-Ngoupo Paul Alain, Abessolo Abessolo Hermine, Mindimi Nkodo Joseph Marie, Bouting Mayaka Georges, Tsoungui Atangana Pierre Claude, Randrianarisaona Fanirisoa, Pélembi Pulchérie, Nzoumbou-Boko Romaric, Coti-Reckoundji Cathy Sandra Goimelle, Manirakiza Alexandre, Rahantamalala Anjanirina, Randremanana Rindra Vatosoa, Tejiokem Mathurin Cyrille, Schoenhals Matthieu
机构信息
Institut Pasteur of Madagascar, Immunology of Infectious Diseases, Antananarivo 101, Madagascar.
Institut Pasteur of Madagascar, Epidemiology and Clinical Research, Antananarivo 101, Madagascar.
出版信息
Vaccines (Basel). 2024 Mar 27;12(4):363. doi: 10.3390/vaccines12040363.
BACKGROUND
The COVID-19 pandemic has affected Madagascar, Cameroon, and the Central African Republic (CAR), with each experiencing multiple waves by mid-2022. This study aimed to evaluate immunity against SARS-CoV-2 strains Wuhan (W) and BA.2 (BA.2) among healthcare workers (HCWs) in these countries, focusing on vaccination and natural infection effects.
METHODS
HCWs' serum samples were analyzed for neutralizing antibodies (nAbs) against W and BA.2 variants, with statistical analyses comparing responses between countries and vaccination statuses.
RESULTS
Madagascar showed significantly higher nAb titers against both strains compared to CAR and Cameroon. Vaccination notably increased nAb levels against W by 2.6-fold in CAR and 1.8-fold in Madagascar, and against BA.2 by 1.6-fold in Madagascar and 1.5-fold in CAR. However, in Cameroon, there was no significant difference in nAb levels between vaccinated and unvaccinated groups.
CONCLUSION
This study highlights the complex relationship between natural and vaccine-induced immunity, emphasizing the importance of assessing immunity in regions with varied epidemic experiences and low vaccination rates.
背景
新冠疫情已影响到马达加斯加、喀麦隆和中非共和国（中非），到2022年年中，每个国家都经历了多波疫情。本研究旨在评估这些国家医护人员对新冠病毒武汉株（W）和BA.2株（BA.2）的免疫力，重点关注疫苗接种和自然感染的影响。
方法
分析医护人员血清样本中针对W和BA.2变体的中和抗体（nAb），并进行统计分析以比较不同国家和疫苗接种状况之间的反应。
结果
与中非和喀麦隆相比，马达加斯加针对这两种毒株的nAb滴度显著更高。疫苗接种显著提高了nAb水平，在中非针对W的水平提高了2.6倍，在马达加斯加提高了1.8倍；在马达加斯加针对BA.2的水平提高了1.6倍，在中非提高了1.5倍。然而，在喀麦隆，接种疫苗组和未接种疫苗组的nAb水平没有显著差异。
结论
本研究突出了自然免疫和疫苗诱导免疫之间的复杂关系，强调了在疫情经历不同且疫苗接种率较低的地区评估免疫力的重要性。
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