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探索乳腺癌的免疫特征:循环肿瘤细胞在诊断和预后方面的最新进展。

Exploring the Immunological Profile in Breast Cancer: Recent Advances in Diagnosis and Prognosis through Circulating Tumor Cells.

机构信息

Physiology Laboratory, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

出版信息

Int J Mol Sci. 2024 Apr 29;25(9):4832. doi: 10.3390/ijms25094832.

Abstract

This review offers a comprehensive exploration of the intricate immunological landscape of breast cancer (BC), focusing on recent advances in diagnosis and prognosis through the analysis of circulating tumor cells (CTCs). Positioned within the broader context of BC research, it underscores the pivotal role of the immune system in shaping the disease's progression. The primary objective of this investigation is to synthesize current knowledge on the immunological aspects of BC, with a particular emphasis on the diagnostic and prognostic potential offered by CTCs. This review adopts a thorough examination of the relevant literature, incorporating recent breakthroughs in the field. The methodology section succinctly outlines the approach, with a specific focus on CTC analysis and its implications for BC diagnosis and prognosis. Through this review, insights into the dynamic interplay between the immune system and BC are highlighted, with a specific emphasis on the role of CTCs in advancing diagnostic methodologies and refining prognostic assessments. Furthermore, this review presents objective and substantiated results, contributing to a deeper understanding of the immunological complexity in BC. In conclusion, this investigation underscores the significance of exploring the immunological profile of BC patients, providing valuable insights into novel advances in diagnosis and prognosis through the utilization of CTCs. The objective presentation of findings emphasizes the crucial role of the immune system in BC dynamics, thereby opening avenues for enhanced clinical management strategies.

摘要

这篇综述全面探讨了乳腺癌(BC)的复杂免疫学特征,重点分析了循环肿瘤细胞(CTC)在诊断和预后方面的最新进展。它在 BC 研究的更广泛背景下强调了免疫系统在塑造疾病进展中的关键作用。本研究的主要目的是综合当前关于 BC 免疫学方面的知识,特别强调 CTC 提供的诊断和预后潜力。本综述采用了对相关文献的深入检查,纳入了该领域的最新突破。方法部分简要概述了方法,特别关注 CTC 分析及其对 BC 诊断和预后的影响。通过本综述,突出了免疫系统与 BC 之间动态相互作用的见解,特别强调了 CTC 在推进诊断方法和完善预后评估方面的作用。此外,本综述提供了客观和有根据的结果,有助于更深入地了解 BC 的免疫学复杂性。总之,本研究强调了探索 BC 患者免疫特征的重要性,通过利用 CTC 为诊断和预后的新进展提供了有价值的见解。客观呈现的研究结果强调了免疫系统在 BC 动态中的关键作用,从而为增强临床管理策略开辟了途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00bf/11084220/99efd3b05df7/ijms-25-04832-g001.jpg

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