CD44：白血病治疗中的癌症干细胞标志物和治疗靶点。
CD44: a cancer stem cell marker and therapeutic target in leukemia treatment.
机构信息
Laboratory Animal Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
出版信息
Front Immunol. 2024 Apr 26;15:1354992. doi: 10.3389/fimmu.2024.1354992. eCollection 2024.
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.
CD44 是一种普遍存在的白细胞黏附分子，参与细胞-细胞相互作用、细胞黏附、迁移、归巢和分化。CD44 可以介导白血病干细胞与周围细胞外基质的相互作用，从而诱导一系列信号通路调节其各种行为。本综述重点讨论了 CD44s/CD44v 作为白血病发生的标志物的影响，并探讨了 CD44 相关干预在临床应用中的研究现状和前景。
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