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一种精油的纳米封装传递了治疗方法。

Nano Encapsulation of An Essential Oil Transpire the Therapeutic Approach.

作者信息

Chhetri Sukanya, Arora Shefali, Parcha Versha, Kumar Deepak, Rawat Devendra Singh

机构信息

Department of Chemistry, University of Petroleum and Energy Studies, Dehradun-248007, Uttarakhand, India.

Department of Chemistry and Pharmaceutical Chemistry, DIBNS, Manduwala, Dehradun-248007, Uttarakhand, India.

出版信息

Curr Pharm Biotechnol. 2024 May 10. doi: 10.2174/0113892010291682240423095306.

Abstract

Essential oils are natural compounds extracted from plants that are volatile and sensitive to heat. Due to their therapeutic value, essential oils are now used in many industries, including the sanitary, cosmetic, agricultural, food, and pharmaceutical industries. These are complex mixtures of a wide range of volatile molecules, including phenol-derived aliphatic and aromatic compounds and terpenoids. Essential oils have been used medicinally since ancient times for their antibacterial, antifungal, antiviral, antiparasitic, insecticidal, sedative, antiinflammatory, and anaesthetic properties. However, essential oils come with inherent limitations; thus, nanoencapsulation is advocated as a remedy as it has the potential to enhance the stability, solubility, and effectiveness of formulations based on essential oils, all while preserving the therapeutic drug blood levels. It is not always viable to use essential oils independently in treatment due to several restrictions; however, nanodelivery technologies appear capable of overcoming these challenges. The therapeutic efficacy that is achieved can be affected by several factors, including the selection of the essential oil as well as the system of nanodelivery. Today, nanoencapsulation is capable of enabling the simultaneous delivery of multiple oils, providing synergistic effects, and facilitating the development of combinational therapies. Additionally, they may have potential applications in preserving food to prolong the shelf life of quickspoiling items and their fragrances. While there is already much research on the characterisation of EOs, this review evaluates the features of the nanoparticles employed for the delivery of essential oils and their impact on the functionality of nano-delivered essential oils and their beneficial uses.

摘要

精油是从植物中提取的天然化合物,具有挥发性且对热敏感。由于其治疗价值,精油目前被应用于许多行业,包括卫生、化妆品、农业、食品和制药行业。它们是多种挥发性分子的复杂混合物,包括酚类衍生的脂肪族和芳香族化合物以及萜类化合物。自古以来,精油就因其抗菌、抗真菌、抗病毒、抗寄生虫、杀虫、镇静、抗炎和麻醉特性而被用于医学。然而,精油存在固有的局限性;因此,纳米包封被提倡作为一种补救方法,因为它有可能提高基于精油的制剂的稳定性、溶解性和有效性,同时保持治疗药物的血药浓度。由于一些限制,单独使用精油进行治疗并不总是可行的;然而,纳米递送技术似乎能够克服这些挑战。所实现的治疗效果可能受到多种因素的影响,包括精油的选择以及纳米递送系统。如今,纳米包封能够实现多种精油的同时递送,提供协同效应,并促进联合疗法的发展。此外,它们在保存食品以延长易腐物品及其香味的保质期方面可能具有潜在应用。虽然已经有很多关于精油特性的研究,但本综述评估了用于递送精油的纳米颗粒的特性及其对纳米递送精油功能及其有益用途的影响。

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