Waghe Tejal, Acharya Neema
Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Apr 20;16(4):e58645. doi: 10.7759/cureus.58645. eCollection 2024 Apr.
Cervical intraepithelial neoplasia (CIN) represents a significant precursor to cervical cancer, posing a considerable threat to women's health globally. This comprehensive review examines recent advancements in the management of CIN, encompassing screening, diagnosis, and treatment modalities. The etiology and pathogenesis of CIN are explored alongside an analysis of traditional and emerging screening techniques, including liquid-based cytology and molecular biomarkers. Treatment options, from minimally invasive procedures to immunotherapy approaches, are evaluated for efficacy and potential impact on patient outcomes. Furthermore, this review highlights the implications of these findings for clinical practice, emphasizing the importance of staying abreast of evolving guidelines and integrating innovative strategies into routine care. Recommendations for future research and practice are provided, emphasizing personalized approaches, disparities in access to care, and the exploration of novel therapeutic avenues. By addressing these challenges and opportunities, this review aims to contribute to the ongoing efforts to mitigate the burden of CIN and cervical cancer, ultimately improving women's health outcomes worldwide.
宫颈上皮内瘤变(CIN)是宫颈癌的重要癌前病变,对全球女性健康构成重大威胁。本综述全面探讨了CIN管理方面的最新进展,包括筛查、诊断和治疗方式。在分析传统和新兴筛查技术(包括液基细胞学和分子生物标志物)的同时,探讨了CIN的病因和发病机制。评估了从微创手术到免疫治疗等各种治疗方案的疗效及其对患者预后的潜在影响。此外,本综述强调了这些研究结果对临床实践的意义,强调紧跟不断演变的指南并将创新策略融入常规护理的重要性。提供了未来研究和实践的建议,强调个性化方法、获得护理的差异以及探索新的治疗途径。通过应对这些挑战和机遇,本综述旨在为减轻CIN和宫颈癌负担的持续努力做出贡献,最终改善全球女性的健康结局。