姜黄素和胡椒碱联合补充对冠状动脉旁路移植术后炎症因子、心脏生物标志物、心房颤动及临床结局的疗效评价。

Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery.

机构信息

Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Cardiovascular Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Clin Nutr ESPEN. 2024 Aug;62:57-65. doi: 10.1016/j.clnesp.2024.05.003. Epub 2024 May 18.

DOI:10.1016/j.clnesp.2024.05.003

PMID:38901949

Abstract

BACKGROUND

Coronary artery bypass graft (CABG) is one of the preferred treatments for patients with heart problems, especially in individuals with other comorbidities and when multiple arteries are narrowed. This study aimed to assess the effects of administrating curcumin-piperine on patients who underwent CABG surgery.

METHODS

This was a randomized, double-blind, placebo-controlled clinical trial, in which 80 eligible adults who underwent CABG surgery, were randomized into 4 groups. Patients received 3 tablets daily for 5 days after the surgery, which contained curcumin-piperine (each tablet contained 500 mg curcumin +5 mg piperine) or a placebo (each tablet contained 505 mg maltodextrin). Group A received 3 placebo tablets, group B received 2 placebos and one curcumin-piperine tablet, group C received 1 placebo and 2 curcumin-piperine tablets, and group D received 3 curcumin-piperine tablets. Before and after the intervention, C-reactive protein (CRP), total antioxidant capacity (TAC), cardiometabolic factors, clinical outcomes, and 28-day mortality were evaluated.

RESULTS

Between-group analysis showed that CRP significantly decreased (P = 0.028), and TAC significantly increased (P = 0.033) after the intervention (Post hoc analysis showed that for CRP, the difference was between group B and D, and for TAC was between group C and D). Between-group analysis also showed that creatine kinase mono-phosphate (CK-MB) marginally reduced (P = 0.077); however, changes for troponin I (P = 0.692), lactate dehydrogenase (LDH) (P = 0.668), ejection fraction (P = 0.340), and arterial fibrillation (P = 0.99) were not significant. Blood urea nitrogen (P = 0.820) and serum creatinine (P = 0.244) did not show notable changes between groups.

CONCLUSION

Supplementation with curcumin-piperine had a promising effect on serum CRP and TAC. It also had a favorable impact on CK-MB among patients who underwent CABG surgery.

TRIAL REGISTRATION

IRCT20201129049534N4, available on https://en.irct.ir/trial/56930.

摘要

背景

冠状动脉旁路移植术（CABG）是治疗心脏问题患者的首选方法之一，尤其是在存在其他合并症和多条动脉狭窄的情况下。本研究旨在评估给予姜黄素-胡椒碱对接受 CABG 手术患者的影响。

方法

这是一项随机、双盲、安慰剂对照的临床试验，共纳入 80 名符合条件的成年患者，他们在接受 CABG 手术后被随机分为 4 组。患者术后连续 5 天每天服用 3 片，药物包含姜黄素-胡椒碱（每片含 500mg 姜黄素+5mg 胡椒碱）或安慰剂（每片含 505mg 麦芽糊精）。A 组服用 3 片安慰剂，B 组服用 2 片安慰剂和 1 片姜黄素-胡椒碱，C 组服用 1 片安慰剂和 2 片姜黄素-胡椒碱，D 组服用 3 片姜黄素-胡椒碱。干预前后评估 C 反应蛋白（CRP）、总抗氧化能力（TAC）、心脏代谢因素、临床结局和 28 天死亡率。

结果

组间分析显示，干预后 CRP 显著降低（P=0.028），TAC 显著升高（P=0.033）（事后分析显示，CRP 方面的差异存在于 B 组和 D 组之间，TAC 方面的差异存在于 C 组和 D 组之间）。组间分析还显示肌酸激酶同工酶单磷酸（CK-MB）略有降低（P=0.077）；然而，肌钙蛋白 I（P=0.692）、乳酸脱氢酶（LDH）（P=0.668）、射血分数（P=0.340）和心房颤动（P=0.99）的变化不显著。血尿素氮（P=0.820）和血清肌酐（P=0.244）在各组之间没有明显变化。