Enteric Infection-Associated Reactive Arthritis: A Systematic Review and Meta-Analysis.

The objective of this systematic review and meta-analysis was to estimate the proportions of individuals infected with , , , , or who develop reactive arthritis. A systematic review was conducted, encompassing English-language articles published before January 2024, sourced from the Embase, PubMed, Scopus, and Web of Science databases. This review included observational studies that reported the occurrence of reactive arthritis (ReA) among patients with , , , , or infections. Data extraction was carried out independently by two reviewers. Subsequently, a random-effects meta-analysis was performed, with heterogeneity assessed using the I value. Additionally, meta-regression was employed to investigate the potential influence of study-level variables on the observed heterogeneity. A total of 87 studies were identified; 23 reported on ReA development after infection, 7 reported on ReA after , 30 reported ReA onset after salmonellosis, 14 reported ReA after shigellosis, and 13 reported ReA after infection. The proportion of patients who developed ReA was 0.03 (95% CI [0.01, 0.06], I = 97.62%); the proportion of patients who developed ReA was 0.01 (95% CI [0.00, 0.06], I = 92.78%); the proportion of patients was 0.04 (95% CI [0.02, 0.08], I = 97.67%); the proportion of patients was 0.01 (95% CI [0.01, 0.03], I = 90.64%); and the proportion of patients who developed ReA was 0.05 (95% CI [0.02, 0.13], I = 96%). A significant proportion of , , and cases resulted in ReA. Nonetheless, it is important to interpret the findings cautiously due to the substantial heterogeneity observed between studies.