与亚急性甲状腺炎和 COVID-19 发展相关的常见人类白细胞抗原。

Common human leucocyte antigensassociated with the development of subacute thyroiditis and COVID-19.

机构信息

Ankara University, Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism, Ankara, Türkiye.

出版信息

Hum Immunol. 2024 Jul;85(4):110834. doi: 10.1016/j.humimm.2024.110834. Epub 2024 Jun 26.

DOI:10.1016/j.humimm.2024.110834

PMID:38936012

Abstract

PURPOSE

Case reports of subacute thyroiditis (SAT) following coronavirus disease-19 (COVID-19) have been reported. Because the relationship between SAT and human leucocyte antigen (HLA) alleles is known, we aimed to determine HLA alleles that may predispose a patient to coronavirus infection and/or post-COVID-19 SAT.

METHOD

This retrospective study was conducted in 51 patients with SAT and 190 healthy bone marrow donor volunteers. HLA-A, -B, -C, -DRB1, and -DQB1 were genotyped using next-generation sequencing. The study population was grouped into four groups according to SAT and COVID-19 history.

RESULTS

The frequency of HLA-DQB104:02 was higher in the COVID-19(-) participants than in the COVID-19(+) participants (=0.045). The presence of HLA-DQB104:02 was associated with a lower risk of developing COVID-19 in all groups. The frequencies of HLA-B35:01, HLA-B35:03, HLA-DRB112:01, and HLA-DRB114:01 were different in the SAT(+) group than in the SAT(-) group in COVID-19(-) group. The frequencies of HLA-C12:03, HLA-DQB106:04, HLA-DRB113:02, and HLA-DRB113:03 were different in the SAT(+) group than in the SAT(-) group in the COVID-19 (+) group. The difference in the frequency of these HLA types remains significant when the four groups are included together as follows: In the COVID-19(+) group, the frequencies of HLA-DRB113:02, and HLA-DRB113:03 were higher in the SAT(+) group than in the SAT(-) group. In the COVID-19(-) group, the frequencies of HLA-B35:03, HLA-DRB112:01, and HLA-DRB1*14:01 were higher in the SAT (+) group than in the SAT(-) group.

CONCLUSION

HLA alleles associated with SAT susceptibility may vary with COVID-19 history.

摘要

目的

有报道称，新冠肺炎（COVID-19）后可发生亚急性甲状腺炎（SAT）病例报告。由于已知 SAT 与人类白细胞抗原（HLA）等位基因之间存在关系，我们旨在确定可能使患者易感染冠状病毒和/或 COVID-19 后发生 SAT 的 HLA 等位基因。

方法

本回顾性研究纳入了 51 例 SAT 患者和 190 名健康骨髓供者志愿者。采用下一代测序对 HLA-A、-B、-C、-DRB1 和-DQB1 进行基因分型。根据 SAT 和 COVID-19 病史，将研究人群分为四组。

结果

COVID-19（-）组中 HLA-DQB104:02 的频率高于 COVID-19（+）组（=0.045）。在所有组中，HLA-DQB104:02 的存在与 COVID-19 发病风险降低相关。在 COVID-19（-）组中，SAT（+）组与 SAT（-）组相比，HLA-B35:01、HLA-B35:03、HLA-DRB112:01 和 HLA-DRB114:01 的频率不同。在 COVID-19（+）组中，SAT（+）组与 SAT（-）组相比，HLA-C12:03、HLA-DQB106:04、HLA-DRB113:02 和 HLA-DRB113:03 的频率不同。当将这四组作为一个整体纳入时，这些 HLA 类型的频率差异仍然显著：在 COVID-19（+）组中，SAT（+）组中 HLA-DRB113:02 和 HLA-DRB113:03 的频率高于 SAT（-）组。在 COVID-19（-）组中，SAT（+）组中 HLA-B35:03、HLA-DRB112:01 和 HLA-DRB1*14:01 的频率高于 SAT（-）组。