miR-196a 在癌症发生和其他疾病中的作用及其作为生物标志物的潜力。

miR-196a in the carcinogenesis and other disorders with an especial focus on its biomarker capacity.

机构信息

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Sciences and Technologies, University of Isfahan, Isfahan, Iran.

出版信息

Pathol Res Pract. 2024 Aug;260:155433. doi: 10.1016/j.prp.2024.155433. Epub 2024 Jun 30.

DOI:10.1016/j.prp.2024.155433

PMID:38959626

Abstract

miR-196a has important roles in the pathoetiology of different disorders ranging from non-malignant to malignant ones. This miRNA is transcribed from two genomic loci, namely HOXC and HOXB on human chromosomes 12 and 17, respectively. The current study aims to summarize the role of miR-196a in different disorders. In the most conducted studies in the framework of cancer, miR-196a has been identified as an oncogene. However, few studies are not conformed to this concept. In head and neck, lung, oral and pancreatic cancers, miR-196a is a possible diagnostic marker. In addition, it has a possible role in the pathoetiology of diabetic nephropathy, Huntington's disease, idiopathic male infertility, keloid, chronic kidney disease and spinal and bulbar muscular atrophy; and is regarded as a biomarker for focal segmental glomerulosclerosis and chronic kidney disease. We aim to recapitulate the role of miR-196a in different malignant and non-malignant disorders.

摘要

miR-196a 在从非恶性到恶性的不同疾病的发病机制中具有重要作用。该 miRNA 分别从人类染色体 12 和 17 上的两个基因组位点 HOXC 和 HOXB 转录而来。本研究旨在总结 miR-196a 在不同疾病中的作用。在癌症相关的大多数研究中，miR-196a 被鉴定为癌基因。然而，少数研究并不符合这一概念。在头颈部、肺、口腔和胰腺癌症中，miR-196a 是一种可能的诊断标志物。此外，它在糖尿病肾病、亨廷顿病、特发性男性不育症、瘢痕疙瘩、慢性肾脏病和脊髓延髓性肌肉萎缩症的发病机制中具有潜在作用，并且被认为是局灶节段性肾小球硬化症和慢性肾脏病的生物标志物。我们旨在总结 miR-196a 在不同恶性和非恶性疾病中的作用。