对耳念珠菌的固有免疫反应。
Innate immune response to Candida auris.
作者信息
Holt Ashley M, Nett Jeniel E
机构信息
Department of Medicine, University of Wisconsin, Madison, WI, USA.
Department of Medicine, University of Wisconsin, Madison, WI, USA; Department of Medical Microbiology & Immunology, University of Wisconsin, Madison, WI, USA.
出版信息
Curr Opin Microbiol. 2024 Aug;80:102510. doi: 10.1016/j.mib.2024.102510. Epub 2024 Jul 3.
Candida auris, a newly emergent fungal species, has been spreading in health care systems and causing life-threatening infections. Intact innate immunity is essential for protection against many invasive fungal infections, including candidiasis. Here, we highlight recent studies exploring immune interactions with C. auris, including investigations using animal models and ex vivo immune cells. We summarize innate immune studies comparing C. auris and the common fungal pathogen Candida albicans. We also discuss how structures of the C. auris cell wall influence immune recognition, the role of soluble host factors in immune recognition, and areas of future study.
耳念珠菌是一种新出现的真菌物种，已在医疗系统中传播并引发危及生命的感染。完整的先天免疫对于抵御包括念珠菌病在内的许多侵袭性真菌感染至关重要。在此，我们重点介绍了近期探索与耳念珠菌免疫相互作用的研究，包括使用动物模型和体外免疫细胞进行的研究。我们总结了比较耳念珠菌和常见真菌病原体白色念珠菌的先天免疫研究。我们还讨论了耳念珠菌细胞壁结构如何影响免疫识别、可溶性宿主因子在免疫识别中的作用以及未来的研究领域。
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