人类与 SARS-CoV2 变体的生物相互作用是否进入了一种灵活的“浮士德式交易”？
Has the human biological interaction with SARS-CoV2 variants entered a pliant "Faustian bargain"?
机构信息
Drug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Belgrade, Serbia.
出版信息
Pharmacol Res Perspect. 2024 Aug;12(4):e1244. doi: 10.1002/prp2.1244.
Abstract
We hypothesize that a "Faustian bargain"-the trading of increased SARS-CoV2 viral infection with a concurrent potential for prevention of life-threatening lower lung infection explains the previous and future morbidity and mortality from COVID-19. Further, this trade-off is made feasible by fundamental principles of thermodynamics and receptor affinity.
摘要
我们假设，一种“浮士德式交易”——用增加 SARS-CoV2 病毒感染的风险来换取同时预防危及生命的下肺部感染的可能性——解释了 COVID-19 以前和现在的发病率和死亡率。此外，这种权衡是通过热力学和受体亲和力的基本原理实现的。
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