来自腺毛菊苣的愈创木烷型倍半萜内酯及其抗神经炎症活性。
Guaianolide sesquiterpene lactones from Cichorium glandulosum and their anti-neuroinflammation activities.
作者信息
Wei Zheyang, Turak Ablajan, Li Bo, Aisa Haji Akber
机构信息
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and the Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and the Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
出版信息
Phytochemistry. 2024 Oct;226:114223. doi: 10.1016/j.phytochem.2024.114223. Epub 2024 Jul 19.
Eight undescribed guaianolide sesquiterpene lactones cicholosumins A-H and twelve known ones were isolated from the aerial parts of Cichorium glandulosum Boiss et Huet. Their structures were established by 1D and 2D NMR spectroscopic data, electronic circular dichroism, quantum chemical calculations and single crystal X-ray diffraction analysis. Compounds 9α-hydroxy-3-deoxyzaluzanin C, epi-8α-angeloyloxycichoralexin, 8-O-methylsenecioylaustricin and lactucin showed strong anti-neuroinflammation activity with IC values of 1.69 ± 0.11, 1.08 ± 0.23, 1.67 ± 0.28 and 1.82 ± 0.27 μM, respectively. The mechanism research indicated that epi-8α-angeloyloxycichoralexin inhibited neuroinflammation through the NF-κB and MAPK pathways.
从腺毛菊苣（Cichorium glandulosum Boiss et Huet）地上部分分离得到8个未报道的愈创木烷型倍半萜内酯类化合物西苣素A - H以及12个已知化合物。通过一维和二维核磁共振光谱数据、电子圆二色光谱、量子化学计算和单晶X射线衍射分析确定了它们的结构。化合物9α - 羟基 - 3 - 脱氧扎鲁扎宁C、表 - 8α - 当归酰氧基苣苦素、8 - O - 甲基千里光酰奥斯特里辛和莴苣苦素表现出较强的抗神经炎症活性，其IC值分别为1.69 ± 0.11、1.08 ± 0.23、1.67 ± 0.28和1.82 ± 0.27 μM。机制研究表明，表 - 8α - 当归酰氧基苣苦素通过NF - κB和MAPK信号通路抑制神经炎症。
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