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噬菌体及其临床应用。

Bacteriophages and Their Clinical Applications.

机构信息

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz 51368, Iran.

Human Microbiome Research Program, and Department of Bacteriology and Immunology, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland.

出版信息

Viruses. 2024 Jun 29;16(7):1051. doi: 10.3390/v16071051.

Abstract

Antimicrobial resistance poses a serious risk to contemporary healthcare since it reduces the number of bacterial illnesses that may be treated with antibiotics, particularly for patients with long-term conditions like cystic fibrosis (CF). People with a genetic predisposition to CF often have recurrent bacterial infections in their lungs due to a buildup of sticky mucus, necessitating long-term antibiotic treatment. infections are a major cause of CF lung illness, and airway isolates are frequently resistant to many antibiotics. Bacteriophages (also known as phages), viruses that infect bacteria, are a viable substitute for antimicrobials to treat infections in individuals with CF. Here, we reviewed the utilization of bacteriophages both in vivo and in vitro, as well as in the treatment of illnesses and diseases, and the outcomes of the latter.

摘要

抗微生物药物耐药性对当代医疗保健构成了严重威胁,因为它减少了可用抗生素治疗的细菌病数量,特别是对于囊性纤维化 (CF) 等慢性病患者。由于粘性粘液的积累,CF 患者的肺部经常发生复发性细菌感染,因此需要长期的抗生素治疗。肺部感染是 CF 肺部疾病的主要原因,气道分离株通常对许多抗生素具有耐药性。噬菌体(也称为噬菌体)是感染细菌的病毒,是治疗 CF 患者感染的替代抗微生物药物。在这里,我们回顾了噬菌体在体内和体外的应用,以及在治疗疾病方面的应用和后者的结果。

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