自然杀伤细胞在溶瘤病毒疗法中的作用：朋友还是敌人？

The Role of Natural Killer Cells in Oncolytic Virotherapy: Friends or Foes?

作者信息

Franks Michael L, An Ju-Hyun, Leavenworth Jianmei W

机构信息

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Graduate Biomedical Sciences Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

出版信息

Vaccines (Basel). 2024 Jun 28;12(7):721. doi: 10.3390/vaccines12070721.

DOI:10.3390/vaccines12070721

PMID:39066359

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11281503/

Abstract

Oncolytic virotherapy (OVT) has emerged as a promising cancer immunotherapy, and is capable of potentiating other immunotherapies due to its capacity to increase tumor immunogenicity and to boost host antitumor immunity. Natural killer (NK) cells are a critical cellular component for mediating the antitumor response, but hold a mixed reputation for their role in mediating the therapeutic efficacy of OVT. This review will discuss the pros and cons of how NK cells impact OVT, and how to harness this knowledge for the development of effective strategies that could modulate NK cells to improve OVT-based therapeutic outcomes.

摘要

溶瘤病毒疗法（OVT）已成为一种有前景的癌症免疫疗法，由于其能够增加肿瘤免疫原性并增强宿主抗肿瘤免疫力，因而有能力增强其他免疫疗法。自然杀伤（NK）细胞是介导抗肿瘤反应的关键细胞成分，但其在介导OVT治疗效果中的作用却褒贬不一。本综述将讨论NK细胞影响OVT的利弊，以及如何利用这些知识来制定有效的策略，调节NK细胞以改善基于OVT的治疗效果。