信使 RNA 疫苗技术：SARS-CoV-2 的成功及 HIV-1 疫苗的前景。
Messenger RNA Vaccine Technology: Success for SARS-CoV-2 and Prospects for an HIV-1 Vaccine.
机构信息
University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Top Antivir Med. 2024 Apr 18;32(2):420-430.
Over the past several years, messenger RNA (mRNA) vaccine has evolved from a term familiar only to vaccine scientists into one easily recognized by much of the general population. This change occurred because of the remarkable success of effective and safe mRNA vaccines during the COVID-19 pandemic that saved countless lives. Although mRNA vaccine technology has a clear use for combating future emerging diseases, its role in fighting currently known pathogens, such as HIV-1, is not well defined. This review summarizes mRNA vaccine technology, highlighting its success during the COVID-19 pandemic. It then addresses past and current efforts to develop a vaccine for HIV-1, including how mRNA vaccine technology has created opportunities in the ongoing search for an effective HIV-1 vaccine.
在过去的几年中，信使 RNA（mRNA）疫苗已经从一个只有疫苗科学家熟悉的术语演变成了大多数公众都容易理解的术语。这种变化的发生是因为在 COVID-19 大流行期间，有效的和安全的 mRNA 疫苗取得了显著成功，挽救了无数生命。尽管 mRNA 疫苗技术在应对未来新兴疾病方面具有明显的用途，但它在对抗目前已知病原体（如 HIV-1）方面的作用尚未得到很好的定义。本综述总结了 mRNA 疫苗技术，重点介绍了其在 COVID-19 大流行期间的成功应用。然后讨论了过去和目前开发 HIV-1 疫苗的努力，包括 mRNA 疫苗技术如何为正在寻找有效的 HIV-1 疫苗的研究创造机会。
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