严重急性呼吸综合征冠状病毒2（SARS-CoV-2）基因和蛋白质的后续趋同进化浪潮

Subsequent Waves of Convergent Evolution in SARS-CoV-2 Genes and Proteins.

作者信息

Focosi Daniele, Spezia Pietro Giorgio, Maggi Fabrizio

机构信息

North-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, Italy.

Laboratory of Virology and Laboratory of Biosecurity, National Institute of Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.

出版信息

Vaccines (Basel). 2024 Aug 5;12(8):887. doi: 10.3390/vaccines12080887.

DOI:10.3390/vaccines12080887

PMID:39204013

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11358953/

Abstract

Beginning in 2022, following widespread infection and vaccination among the global population, the SARS-CoV-2 virus mainly evolved to evade immunity derived from vaccines and past infections. This review covers the convergent evolution of structural, nonstructural, and accessory proteins in SARS-CoV-2, with a specific look at common mutations found in long-lasting infections that hint at the virus potentially reverting to an enteric sarbecovirus type.

摘要

自2022年起，在全球人群中广泛感染和接种疫苗之后，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）主要朝着逃避免疫的方向进化，这些免疫源自疫苗接种和既往感染。本综述涵盖了SARS-CoV-2结构蛋白、非结构蛋白和辅助蛋白的趋同进化，特别关注在长期感染中发现的常见突变，这些突变暗示该病毒可能正在向肠道乙型冠状病毒属类型转变。