IGF 信号在心脏健康和疾病中的作用。

IGF Signaling in the Heart in Health and Disease.

机构信息

Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.

Pirogov Russian National Research Medical University, Moscow, 117997, Russia.

出版信息

Biochemistry (Mosc). 2024 Aug;89(8):1402-1428. doi: 10.1134/S0006297924080042.

DOI:10.1134/S0006297924080042

PMID:39245453

Abstract

One of the most vital processes of the body is the cardiovascular system's proper operation. Physiological processes in the heart are regulated by the balance of cardioprotective and pathological mechanisms. The insulin-like growth factor system (IGF system, IGF signaling pathway) plays a pivotal role in regulating growth and development of various cells and tissues. In myocardium, the IGF system provides cardioprotective effects as well as participates in pathological processes. This review summarizes recent data on the role of IGF signaling in cardioprotection and pathogenesis of various cardiovascular diseases, as well as analyzes severity of these effects in various scenarios.

摘要

人体最重要的生理过程之一就是心血管系统的正常运作。心脏的生理过程受到心脏保护和病理机制之间平衡的调节。胰岛素样生长因子系统（IGF 系统，IGF 信号通路）在调节各种细胞和组织的生长和发育方面起着关键作用。在心肌中，IGF 系统提供心脏保护作用，并参与病理过程。本综述总结了 IGF 信号在各种心血管疾病的心脏保护和发病机制中的作用的最新数据，并分析了在各种情况下这些作用的严重程度。