端粒动力学作为肠道微生物群-宿主相互作用的介导者。
Telomere dynamics as mediators of gut microbiota-host interactions.
机构信息
Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, Øster Farimagsgade 5, DK-1353 Copenhagen, University of Copenhagen, Denmark.
Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, Øster Farimagsgade 5, DK-1353 Copenhagen, University of Copenhagen, Denmark.
出版信息
Trends Cell Biol. 2024 Oct;34(10):805-808. doi: 10.1016/j.tcb.2024.08.003. Epub 2024 Sep 9.
The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.
高度增殖的肠道组织表现出端粒的快速缩短，并对宿主生物体产生全身性影响。最近的研究表明，肠道端粒长度动态与肠道微生物组的组成和活性之间的相互作用具有双向性，从而将不同脊椎动物物种的炎症、失调和衰老过程联系起来。
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