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Breaking barriers: the latest insights into KRAS G12C inhibitors.

作者信息

Attieh Fouad, Kourie Hampig Raphaël

机构信息

Faculty of Medicine, Saint Joseph University of Beirut, Beirut, 11072180, Lebanon.

Department of Hematology-Oncology, Faculty of Medicine, Saint Joseph University of Beirut, Beirut, 11072180, Lebanon.

出版信息

Future Oncol. 2024;20(35):2685-2688. doi: 10.1080/14796694.2024.2394009. Epub 2024 Sep 12.

Abstract
摘要

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Osimertinib with or without Chemotherapy in -Mutated Advanced NSCLC.
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3
Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated G12C.
N Engl J Med. 2023 Dec 7;389(23):2125-2139. doi: 10.1056/NEJMoa2308795. Epub 2023 Oct 22.
4
KRAS-independent feedback activation of wild-type RAS constrains KRAS inhibitor efficacy.
Cell Rep. 2022 Jun 21;39(12):110993. doi: 10.1016/j.celrep.2022.110993.
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KRAS mutation: from undruggable to druggable in cancer.
Signal Transduct Target Ther. 2021 Nov 15;6(1):386. doi: 10.1038/s41392-021-00780-4.
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EGFR Blockade Reverts Resistance to KRAS Inhibition in Colorectal Cancer.
Cancer Discov. 2020 Aug;10(8):1129-1139. doi: 10.1158/2159-8290.CD-20-0187. Epub 2020 May 19.
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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Nature. 2013 Nov 28;503(7477):548-51. doi: 10.1038/nature12796. Epub 2013 Nov 20.

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