定义家族长寿，并为出生队列中的无偏表观遗传学研究开发家族长寿评分。
Defining familial longevity and developing a familial longevity score for unbiased epigenetic studies in a birth cohort.
机构信息
Department of Pediatric Pneumology & Allergy, University Children's Hospital Regensburg (KUNO), of the University of Regensburg & the Order of St. John at the St. Hedwig Hospital, Regensburg, Germany.
Science & Innovation Campus Regensburg (WECARE) of the Order of St. John at the St. Hedwig Hospital, Regensburg, Germany.
出版信息
Epigenomics. 2024;16(17):1149-1158. doi: 10.1080/17501911.2024.2370760. Epub 2024 Sep 12.
Longevity accumulating in families has genetic and epigenetic components. To study early and unbiased epigenetic predictors of longevity prospectively, a birth cohort would be ideal. However, the original family longevity selection score (FLoSS) focuses on populations of elderly only. In the German birth cohort KUNO-Kids we assessed when information for such scores may be best collected and how to calculate an adapted FLoSS. A total of 551 families contributed to adapted FLoSS, with a mean score of -0.15 (SD 2.33). Adapted FLoSS ≥7 as a marker of exceptional longevity occurred in 3.3% of families, comparable to original FLoSS in elderly. An adapted FLoSS from data collectable postnatally may be a feasible tool to study unbiased epigenetic predictors for longevity.
家族长寿的积累既有遗传因素，也有表观遗传因素。为了前瞻性地研究长寿的早期和无偏表观遗传预测因子，出生队列将是理想的选择。然而，最初的家族长寿选择评分（FLoSS）仅关注老年人群。在德国出生队列 KUNO-Kids 中，我们评估了何时可以最佳地收集此类评分的信息，以及如何计算适应性 FLoSS。共有 551 个家庭对适应性 FLoSS 做出了贡献，平均得分为-0.15（SD 2.33）。适应性 FLoSS≥7 作为异常长寿的标志物出现在 3.3%的家庭中，与老年人的原始 FLoSS 相当。从产后可收集的数据中得出的适应性 FLoSS 可能是研究长寿无偏表观遗传预测因子的一种可行工具。
Zotero 插件