具有抗……抗菌活性的植物，绿色兽医药理学应用的荟萃分析

Plants with Antimicrobial Activity against , a Meta-Analysis for Green Veterinary Pharmacology Applications.

作者信息

De Fazio Rosario, Oppedisano Francesca, Caioni Giulia, Tilocca Bruno, Piras Cristian, Britti Domenico

机构信息

Department of Health Sciences, "Magna Græcia University" of Catanzaro, Campus Universitario "Salvatore Venuta" Viale Europa, 88100 Catanzaro, Italy.

Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.

出版信息

Microorganisms. 2024 Aug 28;12(9):1784. doi: 10.3390/microorganisms12091784.

DOI:10.3390/microorganisms12091784

PMID:39338459

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11434269/

Abstract

Antimicrobial resistance (AMR) poses a critical global health threat, necessitating innovative strategies to combat infectious diseases. Plants and their extracts offer alternatives/support to traditional antibiotics, and their diverse phytocomplexes with antimicrobial properties can be exploited. The Mediterranean hosts a high number of biodiverse plant species known for their bioactive compounds. This study focuses on identifying plant species and phytochemical constituents with antimicrobial activity against (). Utilizing a systematic literature review and meta-analysis approach, we screened 3037 entries, yielding 70 studies suitable for MIC (minimum inhibitory concentration) annotation. The results highlighted spp., spp. and as the most effective plants with average MICs of, respectively, 0.144 mg/mL, 0.260 mg/mL, and 0.140 mg/mL. These results might help to fight AMR via the discovery of complementary natural antimicrobial agents to support the development of green veterinary pharmacology. Further exploration of these resources promises valuable insights for future support to antimicrobial strategies.

摘要

抗菌药物耐药性（AMR）对全球健康构成了严重威胁，因此需要创新策略来对抗传染病。植物及其提取物为传统抗生素提供了替代方案或支持，其具有抗菌特性的多种植物复合物可加以利用。地中海地区拥有大量以生物活性化合物而闻名的生物多样性植物物种。本研究的重点是鉴定对（）具有抗菌活性的植物物种和植物化学成分。通过系统的文献综述和荟萃分析方法，我们筛选了3037条记录，得到了70项适合进行最低抑菌浓度（MIC）注释的研究。结果突出显示，[具体植物名称1]属、[具体植物名称2]属和[具体植物名称3]是最有效的植物，其平均MIC分别为0.144毫克/毫升、0.260毫克/毫升和0.140毫克/毫升。这些结果可能有助于通过发现补充性天然抗菌剂来对抗AMR，以支持绿色兽医药理学的发展。对这些资源的进一步探索有望为未来对抗菌策略的支持提供宝贵见解。