表观遗传学与表观基因组学之间的区别。
The distinction between epigenetics and epigenomics.
作者信息
Struhl Kevin
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Genet. 2024 Dec;40(12):995-997. doi: 10.1016/j.tig.2024.10.002. Epub 2024 Oct 24.
Abstract
'Epigenetics' is the process by which distinct cell types or cell states are inherited through multiple cell divisions. 'Epigenomics' refers to DNA-associated physical and functional entities including histone modifications and DNA methylation, not concepts of inheritance. Conflating epigenetics and epigenomics is confusing and causes misunderstanding of a fundamental biological process.
摘要
“表观遗传学”是指不同细胞类型或细胞状态通过多次细胞分裂得以遗传的过程。“表观基因组学”指的是与DNA相关的物理和功能实体，包括组蛋白修饰和DNA甲基化，而非遗传概念。将表观遗传学和表观基因组学混为一谈会造成混淆，并导致对一个基本生物学过程的误解。
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