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评估加巴喷丁类药物和阿片类药物减量工具包(GOTT)在英格兰东北部初级医疗环境中的可行性。

Assessing the feasibility of the GOTT (Gabapentinoid and Opioid Tapering Toolkit) in a primary care setting in North-East England.

作者信息

Johnson Lucy, Cole Frances, Kinchin Rebecca, Francis Andrea, Winiarek Konrad, Hampshire Kate, Chazot Paul

机构信息

Department of Anthropology, Durham University, Durham, UK.

Live well with Pain; Wolfson Research Institute for Health and Wellbeing, Durham University, Durham, UK.

出版信息

Br J Pain. 2024 Oct 20:20494637241291534. doi: 10.1177/20494637241291534.

Abstract

OBJECTIVE

To assess the feasibility and possible impacts of implementation of systematic non-pharmacological interventions to reduce the level of prescribing of opioid and gabapentinoid analgesics for chronic non-cancer pain (CNCP), particularly high-dose prescriptions, through a proof-of-concept study in a deprived area (second lowest decile) primary care practice in North-East England.

PARTICIPANT

Twenty-five primary care staff (clinical and non-clinical) of which 18 clinicians received the intervention.

INTERVENTION USED IN THIS STUDY PRACTICE KNOWN AS GOTT GABAPENTINOID AND OPIOID TOOLKIT

All clinicians received an educational skills programme to support patient pain self-management, tailored on the clinicians' self-assessment of their learning needs, embedding both clinician skill learning and patient self-care resources for rapid access within consultations into a GP clinical management computer system.

OUTCOME MEASURES

Clinical staff completed questionnaires before and after the GOTT intervention to assess levels of knowledge and confidence in their own skills to support chronic pain self-management across several domains. Prescription data were used to measure changes in opioid and gabapentinoid prescribing at the practice across the 12-month intervention and 30-month follow-up period.

RESULTS

Prescribing of opioid and gabapentinoid/pregabalin decreased substantially in the practice across the intervention period (c. 90% in high-dose opioid [ = .0118], and 15% gabapentin/pregabalin prescriptions, respectively), over a one-year period during the COVID-19 pandemic. Follow-up analysis showed 100% and c.50% reductions, respectively, in December 2022. The questionnaire data showed an increase in clinician confidence in skills to enable self-management over the intervention period, overall ( = .044) and, specifically across three of the five domains measured: supporting behavioural change ( = .028), supporting self-care ( = .008), and managing difficult consultations ( = .011).

CONCLUSION

The GOTT intervention program provided some initial evidence of a proof-of-concept for the implementation of a systematic non-pharmacological pain management skills and resources programme addressing lack of confidence in skills to introduce and support self-management and reduce use of strong opioids and gabapentinoids.

摘要

目的

通过在英格兰东北部一个贫困地区(十分位数排名第二低)的基层医疗实践中开展的概念验证研究,评估实施系统性非药物干预措施以降低慢性非癌性疼痛(CNCP)患者阿片类药物和加巴喷丁类镇痛药处方量,尤其是高剂量处方量的可行性及可能产生的影响。

参与者

25名基层医疗工作人员(包括临床和非临床人员),其中18名临床医生接受了干预。

本研究实践中使用的干预措施称为GOTT加巴喷丁类和阿片类药物工具包:所有临床医生都接受了一项教育技能项目,以支持患者疼痛自我管理,该项目根据临床医生对自身学习需求的自我评估进行量身定制,将临床医生技能学习和患者自我护理资源整合到全科医生临床管理计算机系统中,以便在会诊时快速获取。

结果指标

临床工作人员在GOTT干预前后完成问卷调查,以评估他们在多个领域支持慢性疼痛自我管理的知识水平和自身技能信心。处方数据用于衡量在为期12个月的干预期和30个月的随访期内,该医疗机构阿片类药物和加巴喷丁类药物处方的变化情况。

结果

在COVID-19大流行的一年期间,该医疗机构在干预期间阿片类药物和加巴喷丁类/普瑞巴林的处方量大幅下降(高剂量阿片类药物下降约90%[P = 0.0118],加巴喷丁/普瑞巴林处方量下降15%)。随访分析显示,到2022年12月,分别下降了100%和约50%。问卷调查数据显示,在干预期间,临床医生在支持自我管理技能方面的信心总体有所增强(P = 0.044),特别是在五个测量领域中的三个领域:支持行为改变(P = 0.028)、支持自我护理(P = 0.008)和处理困难会诊(P = 0.011)。

结论

GOTT干预项目为实施系统性非药物疼痛管理技能和资源项目提供了一些初步的概念验证证据,该项目旨在解决在引入和支持自我管理技能方面缺乏信心的问题,并减少强效阿片类药物和加巴喷丁类药物的使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/317c/11803609/b090d0fbb963/10.1177_20494637241291534-fig1.jpg

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