神经营养因子与血小板在神经疾病中的联系。
The link between BDNF and platelets in neurological disorders.
作者信息
Bouhaddou Nezha, Mabrouk Meryem, Atifi Farah, Bouyahya Abdelhakim, Zaid Younes
机构信息
Physiology and Physiopathology Team, Genomics of Human Pathologies Research Center, Faculty of Sciences, Mohammed V University, Rabat, Morocco.
Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University, Rabat, Morocco.
出版信息
Heliyon. 2024 Oct 11;10(21):e39278. doi: 10.1016/j.heliyon.2024.e39278. eCollection 2024 Nov 15.
Platelets are considered one of the most important reservoirs not only of growth factors, but also of neurotrophic factors that could contribute to the repair of vascular lesions and the prevention of neurological deterioration. Among these factors, Brain-Derived Neurotrophic Factor (BDNF) - a protein belonging to the neurotrophin family - is widely expressed both in the hippocampus and in platelets. Platelets constitute an important reservoir of BDNF; however, little is known about the factors modulating its release into the circulation and whether anti-platelet drugs affect this secretion. In this review, we have discussed the link between BDNF and platelets and their role in neurological disorders.
血小板不仅被认为是生长因子的最重要储存库之一，也是神经营养因子的重要储存库，这些因子有助于血管损伤的修复和预防神经功能恶化。在这些因子中，脑源性神经营养因子（BDNF）——一种属于神经营养因子家族的蛋白质——在海马体和血小板中均有广泛表达。血小板是BDNF的重要储存库；然而，关于调节其释放到循环中的因素以及抗血小板药物是否会影响这种分泌，我们却知之甚少。在这篇综述中，我们讨论了BDNF与血小板之间的联系及其在神经疾病中的作用。
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