The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population.

BACKGROUND

LncRNAs play diverse roles and participate in various biological processes within the human body. It has been frequently reported that they are involved in the occurrence and development of recurrent spontaneous miscarriage. , a crucial player in several types of cancers, may also have implications for recurrent spontaneous miscarriage risk. However, the correlation between rs13252298 A > G polymorphism and this risk remains unclear. In summary, we conducted the following experiments to investigate the association between the polymorphic site rs13252298 and susceptibility to recurrent spontaneous miscarriage.

METHOD

Our research included 695 healthy controls and 413 patients with recurrent spontaneous miscarriage from southern China. Genotyping was performed using the TaqMan method.

RESULT

Our findings revealed that there is a relationship between rs13252298 A > G polymorphism and lower susceptibility to recurrent spontaneous miscarriage (AG and AA: adjusted OR = 0.794, 95% CI = 0.527-1.196,  = 0.2696; GG and AA: adjusted OR = 0.705, 95% CI = 0.542-0.917,  = 0.0092; dominant model: adjusted OR = 0.722, 95% CI = 0.563-0.926,  = 0.0104; recessive model: adjusted OR = 0.949, 95% CI = 0.644-1.398,  = 0.7912).

CONCLUSION

The results of our study demonstrate that the rs13252298 A > G allele may contribute to a decreased risk of recurrent spontaneous miscarriage. The rs13252298 polymorphism could potentially serve as a biomarker for detecting recurrent spontaneous miscarriage risk and aiding prevention efforts.