肥胖与癌症之间关系的证据日益增多以及减肥手术的作用。
THE GROWING EVIDENCE OF THE RELATIONSHIP BETWEEN OBESITY AND CANCER AND THE ROLE OF BARIATRIC SURGERY.
作者信息
Kassab Paulo, Ferraz Álvaro Antônio Bandeira, Mitidieri Anna Clara Hebling, Berti Luiz Vicente, Santo Marco Aurélio, Szego Tiago, Zanon Caio de Carvalho, Castro Osvaldo Antônio Prado, Freitas Junior Wilson Rodrigues de, Ilias Elias Jirjoss, Malheiros Carlos Alberto, Valez Antônio Carlos, Campos Antônio Carlos Ligocki
机构信息
Santa Casa de São Paulo, Faculdade de Ciências Médicas, Department of Surgery - São Paulo (SP), Brazil.
Universidade Federal de Pernambuco, Hospital Universitêrio, Department of Surgery - Recife (PE), Brazil.
出版信息
Arq Bras Cir Dig. 2024 Dec 2;37:e1838. doi: 10.1590/0102-6720202400044e1838. eCollection 2024.
Obesity is recognized as a significant risk factor for various types of cancer. Although the incidence of some types of cancer across various primary sites is decreasing due to specific prevention measures (screening programs, smoking cessation), the incidence of neoplasms in the young population shows a significant increase associated with obesity. There is sufficient evidence to say that bariatric surgery has been shown to significantly lower the risk of developing obesity-associated cancers, which are linked to metabolic dysregulation, chronic low-grade systemic inflammation, and hormonal alterations such as elevated levels of insulin and sex hormones.
肥胖被认为是各类癌症的一个重要风险因素。尽管由于特定的预防措施（筛查项目、戒烟），不同原发部位的某些类型癌症的发病率正在下降，但年轻人群中肿瘤的发病率却因肥胖而显著上升。有充分证据表明，减重手术已被证明能显著降低患肥胖相关癌症的风险，这些癌症与代谢失调、慢性低度全身炎症以及激素改变（如胰岛素和性激素水平升高）有关。
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