癌症中的SE-lncRNAs：分类、亚细胞定位、功能及相应转录因子

SE-lncRNAs in Cancer: Classification, Subcellular Localisation, Function and Corresponding TFs.

作者信息

Bao Yuxin, Teng Songling, Zhai Hanjie, Zhang Yuanzhuang, Xu Yeqiu, Li Chenghao, Chen Zhenjun, Ren Fu, Wang Yong

机构信息

Fourth Department of Orthopaedic Surgery, Central Hospital Affiliated To Shenyang Medical College, Shenyang, Liaoning, P. R. China.

Department of Hand Surgery, Central Hospital Affiliated To Shenyang Medical College, Shenyang, Liaoning, P. R. China.

出版信息

J Cell Mol Med. 2024 Dec;28(24):e70296. doi: 10.1111/jcmm.70296.

DOI:10.1111/jcmm.70296

PMID:39690143

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11652108/

Abstract

Emerging evidence highlights certain long noncoding RNAs (lncRNAs) transcribed from or interacting with super-enhancer (SE) regulatory elements. These lncRNAs, known as SE-lncRNAs, are strongly linked to cancer and regulate cancer progression through multiple interactions with downstream targets. The expression of SE-lncRNAs is controlled by various transcription factors (TFs), and dysregulation of these TFs can contribute to cancer development. In this review, we discuss the characteristics, classification and subcellular distribution of SE-lncRNAs and summarise the role of key TFs in the transcription and regulation of SE-lncRNAs. Moreover, we examine the distinct functions and potential mechanisms of SE-lncRNAs in cancer progression.

摘要

新出现的证据表明，某些长链非编码RNA（lncRNA）由超级增强子（SE）调控元件转录产生或与其相互作用。这些lncRNA被称为SE-lncRNA，与癌症密切相关，并通过与下游靶点的多种相互作用来调节癌症进展。SE-lncRNA的表达受多种转录因子（TF）控制，这些TF的失调可能导致癌症发展。在这篇综述中，我们讨论了SE-lncRNA的特征、分类和亚细胞分布，并总结了关键TF在SE-lncRNA转录和调控中的作用。此外，我们还研究了SE-lncRNA在癌症进展中的独特功能和潜在机制。