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应对多发性骨髓瘤的经济负担:嵌合抗原受体T细胞(CAR-T)和双特异性抗体疗法成本效益的见解

Navigating the Economic Burden of Multiple Myeloma: Insights into Cost-effectiveness of CAR-T and Bispecific Antibody Therapies.

作者信息

Keesari Praneeth Reddy, Samuels Diana, Vegivinti Charan Thej Reddy, Pulakurthi Yashwitha Sai, Kudithi Revathi, Dhar Meekoo, Janakiram Murali

机构信息

Department of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.

Department of Pharmacy, City of Hope National Medical Center, Duarte, CA, USA.

出版信息

Curr Hematol Malig Rep. 2025 Jan 4;20(1):3. doi: 10.1007/s11899-024-00748-5.

Abstract

PURPOSE OF REVIEW

Multiple myeloma is a chronic malignancy and with evolving treatment options, understanding the economic burden and cost-effectiveness of therapies is crucial for clinicians and researchers.

RECENT FINDINGS

In this, we review the recent approval of Bispecific antibodies and CAR-T for myeloma and their cost implications, including direct and indirect costs. We compare this to current regimens and provide cost comparisons in this review. We conclude that the use of more effective therapies such as CAR-T in earlier lines of therapies may be more cost-effective depending on the country and model used. Further studies are essential to better understand the cost-effectiveness of bispecific antibodies including head-to-head comparisons to CAR-T therapy.

摘要

综述目的

多发性骨髓瘤是一种慢性恶性肿瘤,随着治疗方案的不断发展,了解治疗的经济负担和成本效益对临床医生和研究人员至关重要。

最新发现

在此,我们回顾双特异性抗体和嵌合抗原受体T细胞(CAR-T)疗法近期获批用于骨髓瘤治疗及其成本影响,包括直接成本和间接成本。我们将其与当前治疗方案进行比较,并在本综述中提供成本对比。我们得出结论,根据所使用的国家和模型,在早期治疗中使用如CAR-T等更有效的疗法可能更具成本效益。进一步的研究对于更好地理解双特异性抗体的成本效益至关重要,包括与CAR-T疗法进行直接对比。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcea/11700040/a91b885c11f5/11899_2024_748_Fig1_HTML.jpg

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