混合精油的草药提取物：一种治疗胃肠动力障碍的网络方法

Herbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders.

作者信息

Budriesi Roberta, Corazza Ivan, Roncioni Simone, Scanferlato Roberta, De Luca Dalila, Marzetti Carla, Gotti Roberto, Rizzardi Nicola, Bergamini Christian, Micucci Matteo, Roncarati Davide, Mattioli Laura Beatrice

机构信息

Food Chemistry and Nutraceutical Laboratory, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.

Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.

出版信息

Nutrients. 2024 Dec 17;16(24):4357. doi: 10.3390/nu16244357.

DOI:10.3390/nu16244357

PMID:39770978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11677010/

Abstract

BACKGROUND

Three herbal extracts ( Willd., Lorentz, and L.) were mixed with three essential oils ( Mill., L., and L.) to formulate a product (HEMEO) whose active compounds include saponins and steroids in , known for their anti-inflammatory properties; glycyrrhizin and flavonoids in , which exhibit gastroprotective and antispasmodic effects; menthol in , contributing with antispasmodic and antimicrobial properties; and anethole and polyphenols in , which modulate intestinal motility and offer antimicrobial activity.

OBJECTIVE

HEMEO was formulated for applications in intestinal motility disorders.

METHODS

HEMEO was evaluated for spontaneous and induced motility effects in isolated guinea pig ileum, colon, and stomach. Ex vivo experiments were conducted using LabChart software v7.0, and the product's antibacterial action against and its antioxidant effects were assessed through disc diffusion and FRAP assays. The presence of the volatile compounds in the formulation was confirmed by GC-MS analysis; the TPC of HEMEO, determined using the Folin-Ciocalteu method, was 9.925 ± 0.42 mg GAE/g.

CONCLUSIONS

HEMEO showed a phenolic content correlated with its antioxidant potential and in addition inhibited growth and demonstrated notable antioxidant properties, suggesting its role as a supportive agent in digestive processes and in managing motility disorders.

摘要

背景

三种草药提取物（毛果一枝香、洛伦茨草、光果一枝香）与三种精油（白千层油、柠檬桉叶油、芳樟醇）混合，制成一种产品（HEMEO），其活性成分包括一枝香中的皂苷和甾体，以其抗炎特性而闻名；甘草中的甘草甜素和黄酮类化合物，具有胃保护和抗痉挛作用；薄荷醇中的薄荷醇，具有抗痉挛和抗菌特性；茴芹中的茴香脑和多酚，可调节肠道蠕动并具有抗菌活性。

目的

制备HEMEO用于肠道动力障碍。

方法

在离体豚鼠回肠、结肠和胃中评估HEMEO对自发和诱导的动力作用。使用LabChart软件v7.0进行体外实验，并通过纸片扩散法和FRAP测定法评估该产品对大肠杆菌的抗菌作用及其抗氧化作用。通过气相色谱-质谱分析确认制剂中挥发性化合物的存在；使用Folin-Ciocalteu法测定的HEMEO的总酚含量为9.925±0.42mg没食子酸当量/g。