采用GPR75治疗肥胖症：揭示这种孤儿GPCR的已知与未知情况。
Adopting GPR75 in treating obesity: unraveling the knowns and unknowns of this orphan GPCR.
作者信息
Jiang Yiao, Zhang Zhao
机构信息
Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Trends Cell Biol. 2025 Feb;35(2):102-104. doi: 10.1016/j.tcb.2024.12.006. Epub 2025 Jan 9.
G protein-coupled receptor 75 (GPR75) is emerging as a promising target for obesity treatment, but its exact role in energy regulation remains unclear. This article explores the latest research on GPR75's molecular function, potential ligands, and therapeutic challenges in addressing obesity.
G蛋白偶联受体75（GPR75）正逐渐成为肥胖治疗的一个有前景的靶点，但其在能量调节中的具体作用仍不清楚。本文探讨了关于GPR75分子功能、潜在配体以及肥胖治疗挑战的最新研究。
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