Raats Jochem H, Brameier Devon T, van der Velde Detlef, Javedan Houman, Weaver Michael J
Brigham and Women's Hospital, Dpt. of Orthopaedic Surgery, Boston, MA, United States; Harvard Medical School Orthopedic Trauma Initiative, Boston, MA, United States; St Antonius hospital, Dpt. of Surgery, Utrecht, Netherlands.
Brigham and Women's Hospital, Dpt. of Orthopaedic Surgery, Boston, MA, United States; Harvard Medical School Orthopedic Trauma Initiative, Boston, MA, United States.
Injury. 2025 May;56(5):112144. doi: 10.1016/j.injury.2025.112144. Epub 2025 Jan 5.
Older adults with rib fractures pose an increasing clinical and financial burden on healthcare. Identifying and addressing the increased risk of adverse outcomes has been a key objective in geriatric co-management of surgical patients. The Comprehensive Geriatric Assessment-based Frailty Index (FI-CGA) is a useful predictor of complications and mortality in older adults, but its value in rib fracture management remains unclear. This study investigates the association between FI-CGA and short- and long-term outcomes of older adults with rib fractures.
Rib fracture patients ≥65 years, with a FI-CGA score available, were retrospectively identified from a single level-I trauma center between 2018 and 2022. FI-CGA scores were categorized as pre-frail (<0.20), mild frailty (0.20-0.29), moderate frailty (0.30-0.39), and severe frailty (≥0.40). Outcome measures included mortality up to two years, length of stay (LOS), complications, and 30-day readmission.
288 patients were included for analysis (57 pre-frail; 66 mildly frail; 61 moderately frail; 104 severely frail). Compared to the pre-frail group, only severely frail patients were at higher risk of 90-day (OR 5.71 [CI 1.29 - 52.67]) and 1-year mortality (OR 6.66 [CI 2.18 - 27.37]), while 2-year mortality was higher in mild (OR 3.77 [CI 1.30 - 12.57]), moderate (OR 4.28 [CI 1.46 - 14.51]) and severe (OR 6.42 [CI 2.43 - 20.11]) frailty groups. Hospital (p=0.183) and ICU LOS (p=0.131) was similar across groups. Severely frail patients were at risk of pneumonia (OR 3.50 [CI 0.95 - 19.48]) and delirium (OR 4.16 [CI 1.33 - 17.40]), while other complications were similar between groups (p=0.679). Adjusted proportional hazard ratios for mortality were significantly higher for moderate frailty (HR 1.99 [CI 1.02 - 3.89]) and severe frailty (HR 2.66 [CI 1.10 - 3.73]). FI-CGA was also a significant predictor if used per 0.01 point (HR 1.03 [CI 1.01 - 1.04)]) and per 0.1 point (HR 1.29 [CI 1.12 - 1.47]).
FI-CGA can identify vulnerable rib fracture patients at risk of in-hospital complications, and short- and long-term mortality. Continuous FI-CGA scores provide a granular and individualized risk assessment. In severely frail patients with rib fractures, FI-CGA may assist in aligning treatment with individual patients' needs and goals of care.
肋骨骨折的老年人给医疗保健带来了日益增加的临床和经济负担。识别并应对不良后果风险的增加一直是老年患者手术共同管理的关键目标。基于综合老年评估的衰弱指数(FI-CGA)是老年人并发症和死亡率的有用预测指标,但其在肋骨骨折管理中的价值仍不明确。本研究调查FI-CGA与肋骨骨折老年人短期和长期预后之间的关联。
从2018年至2022年期间的一个一级创伤中心回顾性识别年龄≥65岁且有FI-CGA评分的肋骨骨折患者。FI-CGA评分分为衰弱前期(<0.20)、轻度衰弱(0.20-0.29)、中度衰弱(0.30-0.39)和重度衰弱(≥0.40)。结局指标包括两年内的死亡率、住院时间(LOS)、并发症和30天再入院率。
纳入288例患者进行分析(57例衰弱前期;66例轻度衰弱;61例中度衰弱;104例重度衰弱)。与衰弱前期组相比,只有重度衰弱患者90天(OR 5.71 [CI 1.29 - 52.67])和1年死亡率(OR 6.66 [CI 2.18 - 27.37])风险更高,而轻度(OR 3.77 [CI 1.30 - 12.57])、中度(OR 4.28 [CI 1.46 - 14.51])和重度(OR 6.42 [CI 2.43 - 20.11])衰弱组2年死亡率更高。各亚组间住院时间(p=0.183)和ICU住院时间(p=0.131)相似。重度衰弱患者有肺炎(OR 3.50 [CI 0.95 - 19.48])和谵妄(OR 4.16 [CI 1.33 - 17.40])风险,而其他并发症在各亚组间相似(p=0.679)。中度衰弱(HR 1.99 [CI 1.02 - 3.89])和重度衰弱(HR 2.66 [CI 1.10 - 3.73])的调整后死亡比例风险显著更高。如果按每0.01分(HR 1.03 [CI 1.01 - 1.04])和每0.1分(HR 1.29 [CI 1.12 - 1.47])使用,FI-CGA也是一个显著的预测指标。
FI-CGA可识别有院内并发症、短期和长期死亡风险的脆弱肋骨骨折患者。连续的FI-CGA评分提供了细致且个体化的风险评估。在重度衰弱的肋骨骨折患者中,FI-CGA可能有助于使治疗与个体患者的需求和护理目标相匹配。