PIN1脯氨酰异构酶通过SREBP2介导的胆固醇生物合成途径促进膀胱癌的发生和发展。
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway.
作者信息
Wang Xue, Lee Derrick, Xu Haibo, Sui Yuan, Meisenhelder Jill, Hunter Tony
机构信息
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California.
Division of Regenerative Medicine, Department of Medicine, University of California San Diego, San Diego, California.
出版信息
Cancer Discov. 2025 Mar 3;15(3):633-655. doi: 10.1158/2159-8290.CD-24-0866.
Abstract
This study provides deeper insights into the regulatory role of the phospho-dependent prolyl isomerase PIN1 in bladder cancer. The identification of the link between PIN1 and SREBP2-mediated transcription and cholesterol biosynthesis offers the potential for developing novel therapeutic strategies for bladder cancer.
摘要
本研究对磷酸化依赖性脯氨酰异构酶PIN1在膀胱癌中的调控作用提供了更深入的见解。PIN1与SREBP2介导的转录及胆固醇生物合成之间联系的确定为开发膀胱癌新的治疗策略提供了可能性。
相似文献
1
PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway.
Cancer Discov. 2025 Mar 3;15(3):633-655. doi: 10.1158/2159-8290.CD-24-0866.
2
Copy number amplification of TTPAL promotes cholesterol biosynthesis and esophageal squamous cell carcinoma progression via elevating NSUN2-mediated m5C modification of SREBP2 mRNA.
J Exp Clin Cancer Res. 2025 Jul 26;44(1):220. doi: 10.1186/s13046-025-03483-8.
3
MiR-181a-driven downregulation of cholesterol biosynthesis through SREBP2 inhibition suppresses uveal melanoma metastasis.
J Exp Clin Cancer Res. 2025 Jul 19;44(1):215. doi: 10.1186/s13046-025-03459-8.
4
Tumor necrosis factor alpha-induced activation of SREBP2 promotes cholesterol biosynthesis in cholestasis.
Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Aug;1870(6):159642. doi: 10.1016/j.bbalip.2025.159642. Epub 2025 Jun 6.
5
Covalent Inhibition of the Peptidyl-Prolyl Isomerase Pin1 by Sulfopin Results in a Broad Impact on the Phosphoproteome of Human Osteosarcoma U2-OS Cells.
Proteomics. 2025 Jun 23:e13980. doi: 10.1002/pmic.13980.
6
Targeting SREBP2 in cancer progression: Molecular mechanisms, oncogenic crosstalk, and therapeutic interventions.
Cell Signal. 2025 Nov;135:112044. doi: 10.1016/j.cellsig.2025.112044. Epub 2025 Aug 4.
7
The central role of Pin1 in age-related cancer signaling pathways.
Semin Cancer Biol. 2025 Sep;114:173-194. doi: 10.1016/j.semcancer.2025.05.011. Epub 2025 May 22.
8
Pin1: Advances in pancreatic cancer therapeutic potential and inhibitors research.
Bioorg Chem. 2024 Dec;153:107869. doi: 10.1016/j.bioorg.2024.107869. Epub 2024 Oct 11.
9
m6A-YTHDF1 Mediated Regulation of GRIN2D in Bladder Cancer Progression and Aerobic Glycolysis.
Biochem Genet. 2024 Jun 29. doi: 10.1007/s10528-024-10875-6.
10
FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.
Front Immunol. 2025 Aug 18;16:1611375. doi: 10.3389/fimmu.2025.1611375. eCollection 2025.
本文引用的文献
1
Cancer statistics, 2024.
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.
2
Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors.
Eur Urol. 2023 Aug;84(2):176-190. doi: 10.1016/j.eururo.2023.03.029. Epub 2023 May 16.
3
Key events in cancer: Dysregulation of SREBPs.
Front Pharmacol. 2023 Mar 8;14:1130747. doi: 10.3389/fphar.2023.1130747. eCollection 2023.
4
Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake.
Neuro Oncol. 2023 Sep 5;25(9):1578-1591. doi: 10.1093/neuonc/noad060.
5
Her-2 Targeted Therapy in Advanced Urothelial Cancer: From Monoclonal Antibodies to Antibody-Drug Conjugates.
Int J Mol Sci. 2022 Oct 21;23(20):12659. doi: 10.3390/ijms232012659.
6
Lipid metabolism in pancreatic cancer: emerging roles and potential targets.
Cancer Commun (Lond). 2022 Dec;42(12):1234-1256. doi: 10.1002/cac2.12360. Epub 2022 Sep 15.
7
An update on antibody-drug conjugates in urothelial carcinoma: state of the art strategies and what comes next.
Cancer Chemother Pharmacol. 2022 Sep;90(3):191-205. doi: 10.1007/s00280-022-04459-7. Epub 2022 Aug 11.
8
Zero-preserving imputation of single-cell RNA-seq data.
Nat Commun. 2022 Jan 11;13(1):192. doi: 10.1038/s41467-021-27729-z.
9
Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infiltration.
BMC Cancer. 2022 Jan 3;22(1):2. doi: 10.1186/s12885-021-09064-0.
10
Single-cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer.
Int J Cancer. 2021 Dec 15;149(12):2099-2115. doi: 10.1002/ijc.33794. Epub 2021 Sep 16.
Zotero 插件