替硝唑联合米诺环素治疗种植体周围炎的临床疗效及安全性
Clinical efficacy and safety of Tinidazole combined with minocycline in treating peri-implantitis.
作者信息
Zhao Li-Li, Yuan Quan, Shen Bao-Lian, Wang Qian
机构信息
Department of Stomatology, North China University of Science and Technology Affiliated Hospital Tangshan 063000, Hebei, China.
Department of Orthodontics and Prosthetics, North China University of Science and Technology Affiliated Hospital Tangshan 063000, Hebei, China.
出版信息
Am J Transl Res. 2024 Dec 15;16(12):7405-7415. doi: 10.62347/MGSA7042. eCollection 2024.
OBJECTIVE
To evaluate the effects of tinidazole (TNZ) combined with minocycline (MINO) on therapeutic effectiveness, bone resorption, and inflammation in peri-implantitis (PI).
METHODS
This retrospective study included 96 PI patients admitted between January 2023 and February 2024. Patients were divided into a control group (n = 46) treated with MINO and a research group (n = 50) treated with TNZ plus MINO. Therapeutic effectiveness, post-treatment plaque biofilm activity at different depths, periodontal indexes [modified plaque index (mPLI), modified sulcus bleeding index (mSBI), probing depth (PD), and peri-implant marginal bone loss (MBL)], inflammatory markers [interleukin (IL)-1β, IL-8, and matrix metalloproteinase-8 (MMP-8)], pain scores [Visual Analogue Scale (VAS)], quality of life [Short Form 36 Item Health Survey (SF-36)], and adverse reactions were compared. Univariate and multivariate analyses were performed to identify factors influencing therapeutic effectiveness.
RESULTS
The research group demonstrated significantly higher therapeutic effectiveness and lower mPLI, mSBI, PD, MBL, and plaque biofilm activity at different depths compared to the control group (all P < 0.05). Additionally, greater reductions in VAS scores and increases in SF-36 scores were observed in the research group post-treatment (both P < 0.05). No severe adverse reactions occurred in either group, and the incidence of adverse events showed no significant inter-group difference (P > 0.05). Univariate analysis revealed that disease duration, history of periodontitis, smoking, and treatment modality were significantly associated with therapeutic effectiveness (all P < 0.05). Multivariate analysis identified smoking as an independent factor influencing treatment outcome.
CONCLUSIONS
TNZ combined with MINO is a highly effective and safe treatment for PI. This combination reduces plaque, alleviates periodontitis, and improves patients' quality of life.
目的
评估替硝唑（TNZ）联合米诺环素（MINO）对种植体周围炎（PI）治疗效果、骨吸收及炎症的影响。
方法
本回顾性研究纳入了2023年1月至2024年2月收治的96例PI患者。患者分为对照组（n = 46），接受米诺环素治疗；研究组（n = 50），接受替硝唑加米诺环素治疗。比较两组的治疗效果、治疗后不同深度的菌斑生物膜活性、牙周指标[改良菌斑指数（mPLI）、改良龈沟出血指数（mSBI）、探诊深度（PD）和种植体周围边缘骨吸收（MBL）]、炎症标志物[白细胞介素（IL）-1β、IL-8和基质金属蛋白酶-8（MMP-8）]、疼痛评分[视觉模拟量表（VAS）]、生活质量[简明健康状况调查量表（SF-36）]及不良反应。进行单因素和多因素分析以确定影响治疗效果的因素。
结果
与对照组相比，研究组的治疗效果显著更高，不同深度的mPLI、mSBI、PD、MBL及菌斑生物膜活性更低（均P < 0.05）。此外，研究组治疗后VAS评分降低幅度更大，SF-36评分升高幅度更大（均P < 0.05）。两组均未发生严重不良反应，不良事件发生率组间差异无统计学意义（P > 0.05）。单因素分析显示，病程、牙周炎病史、吸烟及治疗方式与治疗效果显著相关（均P < 0.05）。多因素分析确定吸烟是影响治疗结局的独立因素。
结论
替硝唑联合米诺环素是治疗PI的高效、安全方案。该联合用药可减少菌斑、减轻牙周炎并改善患者生活质量。
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