哺乳动物昼夜节律转录调控中的表观遗传机制。
Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals.
作者信息
Mao Wei, Ge Xingnan, Chen Qianping, Li Jia-Da
机构信息
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310000, China.
Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310000, China.
出版信息
Biology (Basel). 2025 Jan 8;14(1):42. doi: 10.3390/biology14010042.
Almost all organisms, from the simplest bacteria to advanced mammals, havea near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and are regulated by circadian genes as well as by related transcription factors. Transcription factors are fundamental to circadian rhythms, influencing gene expression, behavior in plants and animals, and human diseases. This review examines the foundational research on transcriptional regulation of circadian rhythms, emphasizing histone modifications, chromatin remodeling, and Pol II pausing control. These studies have enhanced our understanding of transcriptional regulation within biological circadian rhythms and the importance of circadian biology in human health. Finally, we summarize the progress and challenges in these three areas of regulation to move the field forward.
几乎所有生物，从最简单的细菌到高等哺乳动物，都有近似24小时的昼夜节律。昼夜节律在不同生命形式中高度保守，受昼夜节律基因以及相关转录因子的调控。转录因子对于昼夜节律至关重要，影响着基因表达、动植物行为以及人类疾病。本综述探讨了昼夜节律转录调控的基础研究，重点关注组蛋白修饰、染色质重塑和RNA聚合酶II暂停控制。这些研究增进了我们对生物昼夜节律中转录调控的理解，以及昼夜生物学在人类健康中的重要性。最后，我们总结了这三个调控领域的进展和挑战，以推动该领域向前发展。
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