活性氧，血管性痴呆的一个潜在治疗靶点。
Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia.
作者信息
White Amanda Louise, Talkington Grant M, Ouvrier Blake, Ismael Saifudeen, Solch-Ottaiano Rebecca J, Bix Gregory
机构信息
Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA.
出版信息
Biomolecules. 2024 Dec 25;15(1):6. doi: 10.3390/biom15010006.
Vascular dementia (VaD) is a progressive neurodegenerative condition prevalent among elderly adults marked by cognitive decline resulting from injured and/or improperly functioning cerebrovasculature with resultant disruptions in cerebral blood flow. Currently, VaD has no specific therapeutics and the exact pathobiology is still being investigated. VaD has been shown to develop when reactive oxygen species (ROS) form from damaged targets at different levels of organization-mitochondria, endothelial cells, or cerebrovasculature. In this review, we highlight how specific ROS molecules may be important in the development of VaD and how they can be targeted as a potential therapeutic for VaD.
血管性痴呆（VaD）是一种在老年人中普遍存在的进行性神经退行性疾病，其特征是由于脑血管系统受损和/或功能异常导致脑血流中断而引起的认知能力下降。目前，VaD尚无特异性治疗方法，其确切的病理生物学机制仍在研究中。研究表明，当活性氧（ROS）在不同组织水平（线粒体、内皮细胞或脑血管系统）的受损靶点形成时，VaD就会发生。在这篇综述中，我们强调了特定的ROS分子在VaD发生发展过程中可能如何发挥重要作用，以及如何将它们作为VaD的潜在治疗靶点。
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