跨膜丝氨酸蛋白酶2（TMPRSS2）作为病毒致病机制中的关键因子：流感病毒和冠状病毒

TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses.

作者信息

Barros de Lima Gilmara, Nencioni Everton, Thimoteo Fábio, Perea Camila, Pinto Rafaela Fuzaro Alves, Sasaki Sergio Daishi

机构信息

Graduate Program of Biosystems, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), São Bernardo do Campo, São Paulo 09606-045, Brazil.

出版信息

Biomolecules. 2025 Jan 7;15(1):75. doi: 10.3390/biom15010075.

DOI:10.3390/biom15010075

PMID:39858469

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11764435/

Abstract

TMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and influenza A enter cells more effectively. Genetic differences in TMPRSS2 may affect people's susceptibility to COVID-19, underscoring the need for studies that consider diverse populations. Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review provides a summary of TMPRSS2 inhibitors currently under study, with some already in clinical trials to test their effectiveness against viral infections. As we uncover more about TMPRSS2's role in pathogenesis, it could open new doors for therapies to combat future outbreaks.

摘要

跨膜丝氨酸蛋白酶2（TMPRSS2）是一种人类跨膜蛋白酶，在包括流感病毒和冠状病毒在内的某些病毒传播中起着关键作用。这种酶通过切割病毒糖蛋白来促进病毒感染，这有助于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和甲型流感等病毒更有效地进入细胞。TMPRSS2的基因差异可能会影响人们对2019冠状病毒病（COVID-19）的易感性，这突出了开展考虑不同人群的研究的必要性。除了传染病，TMPRSS2还与某些癌症有关，这表明它可能是药物开发的一个有价值的靶点。这篇综述总结了目前正在研究的TMPRSS2抑制剂，其中一些已经进入临床试验以测试其对病毒感染的有效性。随着我们对TMPRSS2在发病机制中的作用了解得更多，它可能为对抗未来疫情的治疗方法打开新的大门。