衰老及衰老相关疾病中的RIP激酶与坏死性凋亡
RIP kinases and necroptosis in aging and aging-related diseases.
作者信息
Yang Yuanxin, Li Xingyan, Zhang Tao, Xu Daichao
机构信息
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Life Med. 2022 Jun 14;1(1):2-20. doi: 10.1093/lifemedi/lnac003. eCollection 2022 Aug.
Aging is a natural process that is characterized by chronic, low-grade inflammation, which represents the primary risk factor in the pathogenesis of a variety of diseases, i.e. aging-related diseases. RIP kinases, in particular RIPK1 and RIPK3, have emerged as master regulators of proinflammatory responses that act either by causing apoptosis and necroptosis or by directly regulating intracellular inflammatory signaling. While, RIPK1/3 and necroptosis are intimately linked to multiple human diseases, the relationship among RIPK1/3, necroptosis, and aging remains unclear. In this review, we discuss current evidence arguing for the involvement of RIPK1/3 and necroptosis in the progression of aging. In addition, we provide updated information and knowledge on the role of RIPK1/3 and necroptosis in aging-related diseases. Leveraging these new mechanistic insights in aging, we postulate how our improved understanding of RIPK1/3 and necroptosis in aging may support the development of therapeutics targeting RIPK1/3 and necroptosis for the modulation of aging and treatment of aging-related diseases.
衰老是一个以慢性低度炎症为特征的自然过程，而慢性低度炎症是多种疾病（即与衰老相关的疾病）发病机制中的主要危险因素。RIP激酶，特别是RIPK1和RIPK3，已成为促炎反应的主要调节因子，它们通过引发细胞凋亡和坏死性凋亡或直接调节细胞内炎症信号传导发挥作用。虽然RIPK1/3和坏死性凋亡与多种人类疾病密切相关，但RIPK1/3、坏死性凋亡和衰老之间的关系仍不清楚。在这篇综述中，我们讨论了支持RIPK1/3和坏死性凋亡参与衰老进程的现有证据。此外，我们提供了关于RIPK1/3和坏死性凋亡在衰老相关疾病中作用的最新信息和知识。利用这些关于衰老的新机制见解，我们推测对RIPK1/3和坏死性凋亡在衰老过程中更好的理解如何支持开发针对RIPK1/3和坏死性凋亡的疗法，以调节衰老和治疗衰老相关疾病。
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