白细胞介素-8促成肿瘤浸润中性粒细胞的功能多样性：癌症免疫治疗的新靶点。
IL-8 contributes to functional diversity of tumor-infiltrating neutrophils: A new target for cancer immunotherapy.
作者信息
Tavukcuoglu Ece, Esendagli Gunes
机构信息
Hacettepe University Cancer Institute, Department of Basic Oncology, Ankara, Türkiye.
Hacettepe University Cancer Institute, Department of Basic Oncology, Ankara, Türkiye.
出版信息
Dev Cell. 2025 Feb 3;60(3):339-341. doi: 10.1016/j.devcel.2025.01.003.
PMID:39904319
Abstract
In this issue of Developmental Cell, Tang et al. identify CD74 neutrophils as a subpopulation promoted by IL-8 in the tumor microenvironment of non-small lung cancer (NSCLC). These CD74 neutrophils support anti-tumor T cell responses and enhance the efficacy of anti-PD-1 immunotherapy and targeted therapy in NSCLC.
摘要
在本期《发育细胞》杂志中，唐等人将CD74阳性中性粒细胞鉴定为非小细胞肺癌（NSCLC）肿瘤微环境中由白细胞介素-8促进的一个亚群。这些CD74阳性中性粒细胞支持抗肿瘤T细胞反应，并增强NSCLC中抗PD-1免疫疗法和靶向疗法的疗效。
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