对长链非编码RNA在肺部疾病发病机制中新兴作用的全面见解与计算机模拟分析；迈向非编码RNA精准医学的一步。

Comprehensive insights and In silico analysis into the emerging role of LincRNAs in lung diseases pathogenesis; a step toward ncRNA precision.

作者信息

Hamdy Nadia M, Zaki Mohamed Bakr, Abdelmaksoud Nourhan M, Elshaer Shereen Saeid, Abd-Elmawla Mai A, Rizk Nehal I, Fathi Doaa, Doghish Ahmed S, Abulsoud Ahmed I

机构信息

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Abassia, Egypt.

Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Menoufia, Egypt.

出版信息

Funct Integr Genomics. 2025 Feb 6;25(1):34. doi: 10.1007/s10142-025-01540-1.

DOI:10.1007/s10142-025-01540-1

PMID:39912974

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11802690/

Abstract

Long non-coding RNAs (lncRNAs) have emerged as essential regulators of gene expression, significantly influencing various biological processes. Approximately half of all lncRNAs are classified as long intergenic non-coding RNAs (lincRNAs), which are situated among coding genes. Recent studies have documented the role of lincRNAs in the pathogenesis of lung diseases, including lung cancer, pulmonary fibrosis, and pulmonary arterial hypertension. These lincRNAs can modulate gene expression through various mechanisms, including epigenetic modifications, transcriptional regulation, and post-transcriptional regulation. By functioning as competing endogenous RNAs (ceRNAs), lincRNAs can affect the activity of microRNAs (miRNAs) and their corresponding target genes. This review delves into the intricate mechanisms by which lincRNAs contribute to the development and progression of various lung diseases. Furthermore, it discusses the potential of lincRNAs as therapeutic targets.

摘要

长链非编码RNA（lncRNAs）已成为基因表达的重要调节因子，对各种生物学过程有显著影响。所有lncRNAs中约有一半被归类为长链基因间非编码RNA（lincRNAs），它们位于编码基因之间。最近的研究记录了lincRNAs在肺部疾病发病机制中的作用，包括肺癌、肺纤维化和肺动脉高压。这些lincRNAs可通过多种机制调节基因表达，包括表观遗传修饰、转录调控和转录后调控。作为竞争性内源性RNA（ceRNAs），lincRNAs可影响微小RNA（miRNAs）及其相应靶基因的活性。本综述深入探讨了lincRNAs促进各种肺部疾病发生和发展的复杂机制。此外，还讨论了lincRNAs作为治疗靶点的潜力。