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针对肌肉减少症的康复策略(ReStart-S)对长期护理机构中患有肌肉减少症的老年人的影响:一项整群随机试验方案

Effect of Reablement Strategies targeting Sarcopenia (ReStart-S) on sarcopenic older adults residing in long term care settings: A protocol for cluster randomized trial.

作者信息

Kumar Prabal, Umakanth Shashikiran, Bruyère Olivier, N Girish

机构信息

Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Department of Medicine, Dr. TMA Pai Hospital, Manipal Academy of Higher Education, Udupi, Karnataka, India.

出版信息

Heliyon. 2025 Jan 24;11(3):e42174. doi: 10.1016/j.heliyon.2025.e42174. eCollection 2025 Feb 15.

Abstract

BACKGROUND

The prevalence of sarcopenia is high among older adults residing in long-term care settings (LTCS). Guidelines to manage sarcopenia cannot be directly implemented among sarcopenic older adults residing in LTCS.

OBJECTIVES

To examine the effectiveness of a codesigned Reablement Strategies targeting Sarcopenia (ReStart-S) program on muscle parameters, physical performance, blood biomarkers and quality of life among sarcopenic older adults residing in LTCS.

METHODS

The study is a cluster randomized trial that will take place in LTCS. A total of 78 sarcopenic older adults will be included, selected through convenience sampling, and diagnosed using the Asian Working Group for Sarcopenia 2019 criteria. The LTCS clusters will be randomized into intervention and control groups. The participants in the intervention group will receive the ReStart-S multicomponent exercise intervention twice a week for a total of six weeks, while those in the control group will continue with their usual daily activities. The primary outcome will be grip strength, and the secondary outcomes will include a short physical performance battery, muscle mass, C-terminal agrin fragment, and quality of life as assessed through the sarcopenia and quality of life-Kannada version questionnaire. The outcomes will be measured at week 0, week 6, week 12, and week 18.

CONCLUSION

ReStart-S program if found to be effective could be implemented globally to manage sarcopenia and promote healthy ageing in older adults, enhancing their independence in LTCS.

摘要

背景

在长期护理机构(LTCS)居住的老年人中,肌肉减少症的患病率很高。针对肌肉减少症的管理指南无法直接应用于居住在LTCS的患有肌肉减少症的老年人。

目的

研究一项针对肌肉减少症的共同设计的康复策略(ReStart-S)计划对居住在LTCS的患有肌肉减少症的老年人的肌肉参数、身体机能、血液生物标志物和生活质量的有效性。

方法

该研究是一项将在LTCS进行的整群随机试验。通过便利抽样纳入总共78名患有肌肉减少症的老年人,并使用2019年亚洲肌肉减少症工作组标准进行诊断。LTCS群组将被随机分为干预组和对照组。干预组的参与者将每周接受两次ReStart-S多组分运动干预,共六周,而对照组的参与者将继续其日常活动。主要结局将是握力,次要结局将包括简短身体机能测试、肌肉量、C末端集聚蛋白片段,以及通过肌肉减少症和生活质量-卡纳达语版问卷评估的生活质量。结局将在第0周、第6周、第12周和第18周进行测量。

结论

如果发现ReStart-S计划有效,则可在全球实施,以管理肌肉减少症并促进老年人的健康老龄化,增强他们在LTCS中的独立性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1c3/11815644/7ce2394d0bb7/gr1.jpg

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