组蛋白甲基化在血管衰老及相关疾病中的作用和机制
Roles and mechanisms of histone methylation in vascular aging and related diseases.
作者信息
Ji Yufei, Chen Zhenzhen, Cai Jun
机构信息
State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
出版信息
Clin Epigenetics. 2025 Feb 23;17(1):35. doi: 10.1186/s13148-025-01842-y.
The global aging trend has posed significant challenges, rendering healthcare for older adults a crucial focus in medical research. Among the numerous health concerns related to aging, vascular aging and dysfunction are important risk factors and underlying causes of age-related diseases. Histone methylation and demethylation, which are involved in gene expression and cellular senescence, are closely associated with the occurrence and development of vascular aging. Consequently, this review aimed to identify the role of histone methylation in the pathogenesis of vascular aging and its potential for treating age-related vascular diseases and provided new insights into therapeutic strategies targeting the vascular system.
全球老龄化趋势带来了重大挑战，使老年人的医疗保健成为医学研究的关键焦点。在与衰老相关的众多健康问题中，血管衰老和功能障碍是重要的风险因素及与年龄相关疾病的潜在病因。参与基因表达和细胞衰老的组蛋白甲基化和去甲基化与血管衰老的发生发展密切相关。因此，本综述旨在确定组蛋白甲基化在血管衰老发病机制中的作用及其治疗与年龄相关血管疾病的潜力，并为针对血管系统的治疗策略提供新见解。
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