2019年至2023年中国贵州分离株的动态血清型分布及抗菌药物耐药性
Dynamic Serotype Distribution and Antimicrobial Resistance of Isolates from 2019 to 2023 in Guizhou, China.
作者信息
Wu Jingtong, You Lv, Liu Yanmin, Long Li, Wang Ming, Wei Xiaoyu, Wang Junhua, Li Shijun
机构信息
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, People's Republic of China.
Laboratory of Bacterial Disease, Experimental Center, Guizhou Provincial Center for Disease Control and Prevention, Guiyang, People's Republic of China.
出版信息
Infect Drug Resist. 2025 Feb 18;18:993-1006. doi: 10.2147/IDR.S492042. eCollection 2025.
INTRODUCTION
, a leading cause of human infectious diarrhea diseases, foodborne illness, and zoonotic infections, poses a significant health burden.
METHODS
A retrospective screening was performed to elucidate the serotype distribution and antimicrobial resistance of 933 human isolates from nine cities (prefectures) in Guizhou province of southwestern China between 2019 and 2023 through slide agglutination and antimicrobial resistance testing.
RESULTS
Fifty-four different serotypes were identified in this study, with . Typhimurium (44.4%) and . Enteritidis (20.7%) being the predominant serotypes, followed by . London (3.1%), . Derby (2.8%), and . Rissen (2.0%). A total of 39 serotypes were reported for the first time in Guizhou province, and 121 isolates (13.0%) could not be classified. The diversity of serotypes in Guizhou has increased from 8 in 2019 to 39 in 2023. In addition, the detection rate of . Enteritidis showed a decreasing trend over time, while the detection rate of . Typhimurium demonstrated an annual increase since 2020. For 933 isolates, a significant majority (94.0%) exhibited resistance to at least one class of antimicrobial agents. The highest resistance observed was to ampicillin (86.4%), followed by resistance to tetracycline (76.3%) and streptomycin (72.8%). Notably, we discovered that the resistance rate to colistin was 4.7%, with 93.2% of these isolates being . Enteritidis. Meanwhile, 78.5% of isolates were demonstrated multidrug resistance (MDR), with the MDR rates for . Rissen and . Typhimurium exceeding 90%. Additionally, 5.7% of isolates were extensively drug-resistant (XDR), with . Typhimurium and . Enteritidis exhibiting XDR rates of 5.1% and 4.1%, respectively. The rate of MDR and XDR in peaked in 2019 and then gradually declined from 2020 to 2022, rising again in 2023.
CONCLUSION
Our research revealed an increasing diversity in serotypes within Guizhou province, alongside significant challenges posed by MDR and a rising XDR rate. Therefore, it is essential to continuously improve the surveillance of , keep track of changes in serotype distribution and dynamic shifts, and strengthen the persistent monitoring of antimicrobial agents.
引言
作为人类感染性腹泻疾病、食源性疾病和人畜共患病感染的主要病因，带来了重大的健康负担。
方法
通过玻片凝集试验和抗菌药物敏感性试验，对2019年至2023年期间从中国西南部贵州省9个市（州）收集的933株人源分离株进行回顾性筛查，以阐明血清型分布和抗菌药物耐药性情况。
结果
本研究共鉴定出54种不同血清型，其中鼠伤寒沙门氏菌（44.4%）和肠炎沙门氏菌（20.7%）为主要血清型，其次为伦敦沙门氏菌（3.1%）、德比沙门氏菌（2.8%）和里森沙门氏菌（2.0%）。贵州省共首次报告了39种血清型，121株分离株（13.0%）无法分型。贵州省沙门氏菌血清型的多样性从2019年的8种增加到2023年的39种。此外，肠炎沙门氏菌的检出率呈逐年下降趋势，而鼠伤寒沙门氏菌的检出率自2020年以来呈逐年上升趋势。对于933株分离株，绝大多数（94.0%）对至少一类抗菌药物耐药。观察到的最高耐药率是对氨苄西林（86.4%），其次是对四环素（76.3%）和链霉素（72.8%）。值得注意的是，我们发现对黏菌素的耐药率为4.7%，其中93.2%的分离株为肠炎沙门氏菌。同时，78.5%的分离株表现为多重耐药（MDR），里森沙门氏菌和鼠伤寒沙门氏菌的MDR率超过90%。此外，5.7%的沙门氏菌分离株为广泛耐药（XDR），鼠伤寒沙门氏菌和肠炎沙门氏菌的XDR率分别为5.1%和4.1%。沙门氏菌的MDR和XDR率在2019年达到峰值，然后在2020年至2022年逐渐下降，2023年再次上升。
结论
我们的研究揭示了贵州省沙门氏菌血清型的多样性不断增加，同时MDR带来了重大挑战，XDR率也在上升。因此，必须持续加强对沙门氏菌的监测，跟踪血清型分布变化和动态转变，并加强对抗菌药物的持续监测。
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