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应对加勒比地区和南美洲的传染病:流行病学见解、抗生素耐药性、免疫紊乱中的相关传染病、全球感染应对措施以及针对具有公共卫生重要性的微生物的实验性抗独特型疫苗候选物。

Tackling Infectious Diseases in the Caribbean and South America: Epidemiological Insights, Antibiotic Resistance, Associated Infectious Diseases in Immunological Disorders, Global Infection Response, and Experimental Anti-Idiotypic Vaccine Candidates Against Microorganisms of Public Health Importance.

作者信息

Justiz-Vaillant Angel, Soodeen Sachin, Gopaul Darren, Arozarena-Fundora Rodolfo, Thompson Reinand, Unakal Chandrashekhar, Akpaka Patrick E

机构信息

Department of Para-Clinical Sciences, University of the West Indies, St. Augustine Campus, St. Augustine 330912, Trinidad and Tobago.

Department of Surgery, Morehouse School of Medicine, Atlanta, GA 30310, USA.

出版信息

Microorganisms. 2025 Jan 27;13(2):282. doi: 10.3390/microorganisms13020282.

Abstract

This paper explores various aspects of microbiology and immunology, with a particular focus on the epidemiology and molecular characterisation of infectious diseases in the Caribbean and South America. Key areas of investigation include tuberculosis (TB), experimental vaccines, and bloodborne pathogens. A retrospective study conducted in Jamaica highlights the significance of early HIV screening, timely diagnosis, and inte-grated care. The paper also examines the challenges posed by nosocomial infections, particularly those caused by antibiotic-resistant Gram-negative bacteria and methicillin-resistant (MRSA), emphasising the critical importance of infection control measures. Additionally, it explores the regional microbiome, the global response to infectious diseases, and immune responses in patients with immunodeficiency disorders such as severe combined immunodeficiency (SCID) and chronic granulomatous disease (CGD), underscoring their heightened susceptibility to a wide range of infections.

摘要

本文探讨了微生物学和免疫学的各个方面,特别关注加勒比地区和南美洲传染病的流行病学和分子特征。主要研究领域包括结核病(TB)、实验性疫苗和血源性病原体。在牙买加进行的一项回顾性研究突出了早期艾滋病毒筛查、及时诊断和综合护理的重要性。本文还研究了医院感染带来的挑战,特别是由耐抗生素革兰氏阴性菌和耐甲氧西林金黄色葡萄球菌(MRSA)引起的感染,强调了感染控制措施的至关重要性。此外,它还探讨了区域微生物群、全球对传染病的应对以及免疫缺陷疾病(如重症联合免疫缺陷(SCID)和慢性肉芽肿病(CGD))患者的免疫反应,强调了他们对多种感染的易感性增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e588/11858333/ceb5db947575/microorganisms-13-00282-g001.jpg

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