细胞表面波形蛋白：免疫疗法的天然人类免疫反应靶点。
Cell surface vimentin: a natural human immune response target for immunotherapy.
作者信息
Glassy Mark C
机构信息
Neuro-Oncology Laboratory, Moores Cancer Center, University of California, San Diego, San Diego, CA, United States.
出版信息
Front Mol Med. 2025 Feb 20;5:1552323. doi: 10.3389/fmmed.2025.1552323. eCollection 2025.
Abstract
Natural human monoclonal antibodies obtained from sentinel lymph nodes of cancer patients identify cell surface vimentin. One of these vimentin-reactive antibodies, pritumumab, has been used to treat brain cancer patients. This review summarizes data on mAbs reactive with cell surface vimentin and their origin from lymph nodes of cancer patients.
摘要
从癌症患者前哨淋巴结获得的天然人单克隆抗体可识别细胞表面波形蛋白。其中一种与波形蛋白反应的抗体——普替单抗，已被用于治疗脑癌患者。本综述总结了与细胞表面波形蛋白反应的单克隆抗体及其源自癌症患者淋巴结的数据。
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