Woehl Lucas de Oliveira, Pereira Emanuel Schumacher
Medical School, Planalto Catarinense University, Lages, SC, Brazil.
Curr Pain Headache Rep. 2025 Mar 10;29(1):58. doi: 10.1007/s11916-025-01374-3.
Chronic pain affects millions worldwide, reducing quality of life and posing a major healthcare challenge. This review aims to explore advancements in neurosurgical interventions for managing chronic pain, focusing on the latest neuromodulation techniques, and addressing how these innovations may offer alternative solutions for these patients.
We reviewed advances in high-frequency spinal cord stimulation, dorsal root ganglion stimulation, and closed-loop neuromodulation systems, which optimize precision in pain control and reduce adverse effects. Improvements in targeted drug delivery enabled more accurate and sustained management of pain, with fewer unfavorable effects than traditional therapies. Additionally, we discussed emerging technologies, including artificial intelligence for personalized treatment adjustment, and gene therapy for addressing pain at a molecular level, innovations that also hold promise for future applications. Neurosurgical techniques have the potential to transform chronic pain management, offering improved control with fewer complications. However, challenges remain regarding accessibility, cost, and long-term efficacy. Further research is needed to refine, expand access, and enhance effectiveness.
慢性疼痛影响着全球数百万人,降低了生活质量,构成了重大的医疗保健挑战。本综述旨在探讨用于管理慢性疼痛的神经外科干预措施的进展,重点关注最新的神经调节技术,并阐述这些创新如何为这些患者提供替代解决方案。
我们回顾了高频脊髓刺激、背根神经节刺激和闭环神经调节系统的进展,这些进展优化了疼痛控制的精准度并减少了不良反应。靶向药物递送的改进使得疼痛管理更加准确和持续,与传统疗法相比不良反应更少。此外,我们讨论了新兴技术,包括用于个性化治疗调整的人工智能,以及用于在分子水平解决疼痛问题的基因治疗,这些创新在未来应用方面也具有前景。神经外科技术有可能改变慢性疼痛的管理方式,提供更好的控制且并发症更少。然而,在可及性、成本和长期疗效方面仍存在挑战。需要进一步研究来完善、扩大可及性并提高有效性。